Load-bearing capacity of an experimental dental implant made of Nb-1Zr.

Although implants have undergone a remarkable development over the past decades, modern implants still show complications that make the improvement of materials necessary. The presented study investigates the load-bearing capacity of an experimental dental implant made of a niobium alloy (Nb1Zr) compared to identical implants made of Ti6Al4V using chewing simulation for artificial aging. Eight implants each with an experimental design were manufactured from Nb1Zr and Ti6Al4V.

Solving the robustness puzzle: The joint impact of optimization approach, robustness metrics, and scenarios on water resources management under deep uncertainty.

The concept of robustness has been widely used in water resources management to identify solutions that perform satisfactorily across a range of plausible future conditions to increase confidence in decision-making in a deeply uncertain future. However, the selection of an appropriate metric to quantify robustness remains challenging due to the existence of multiple choices reflecting different risk preferences. In addition, different scenarios can be used to represent plausible future conditions, which adds another layer of complexity to solution identification.

Expensive today but cheaper tomorrow: lifetime costs of an active middle ear implant compared to alternative treatment options.

Background: When choosing between different treatment options, implants often appear too costly. However, this perspective does not take future costs into account. This article evaluates lifetime costs for different surgical interventions to treat hearing loss.

Aggressive Lymphoma after CD19 CAR T-Cell Therapy.

The development of a fatal, clonal, autonomously proliferating CD4-CD8- chimeric antigen receptor (CAR)+ peripheral T-cell lymphoma (PTCL) occurred 1 month after a patient received treatment with tisagenlecleucel for relapsed primary central nervous system lymphoma. The PTCL had a clonal T-cell receptor rearrangement, which was already detectable in the apheresis product for CAR T-cell manufacturing and 7 months earlier for autologous transplantation. Somatic and mutations in CD34+ stem cells and their progeny were detected in the PTCL, in the apheresis specimen that was obtained for CAR T-cell production, and in the autotransplant.

Predicting burn probability: Dimensionality reduction strategies enable accurate and computationally efficient metamodeling.

Predicting the probability that a given location will be burnt by a wildfire is an important part of understanding the risk that wildfires pose and how our management actions (e.g., prescribed burning) can reduce this risk.