Publications by authors named "H J Ludwig"
Manganese (Mn) is an essential and important metal; however, overexposures lead to adverse neurological outcomes. Nonoccupational Mn overexposure occurs primarily through consumption of Mn-contaminated drinking water (DW). Sex differences in terms of nervous and immune systems' responsiveness to excessive Mn in the DW are understudied.
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- Measuring overall survival (OS) is the best way to see how well new treatments for multiple myeloma work in big studies, but it's getting harder to use OS since treatments are improving and they want to approve new medicines faster.
- Other measures like progression-free survival (PFS) and response to treatment are being used to help decide if a treatment is good enough for approval, and the FDA even thinks minimal residual disease (MRD) can be used for quick approval.
- This review talks about how PFS can sometimes be tricky to understand for different groups of patients, and it looks at how to design studies that take these differences into account so doctors can find the right treatments for the right people.
Understanding the impact of induction and maintenance therapy on patients' quality of life (QoL) is important for treatment selection. This study aims to compare patient-reported QoL between patients treated with KTd or KRd induction therapy and K maintenance therapy or observation. QoL was assessed using the EORTC QOL-C 30 and QOL-MY20 questionnaires in the AGMT-02 study, in which 123 patients with newly diagnosed transplant ineligible multiple myeloma were randomized to nine cycles of either KTd or KRd induction therapy, followed by 12 cycles of K maintenance therapy, or observation.
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