Using Implementation Science to Assess Barriers to Agreement on Sedation Goal Setting and Assessment.

Objectives: Sedation assessment and goal setting using a validated assessment tool are key components of the ICU Liberation bundle. Appropriate integration of these bundle elements into daily practice remains challenging. Understanding barriers is an important step toward implementation of these best practice bundle elements.

Allergens in ophthalmic medicaments in New Zealand.

Background/objectives: Eyelid allergic contact dermatitis (ACD) attributed to ophthalmic medications is often underreported, which can result in poor outcomes. Patch testing for eyelid ACD requires up-to-date knowledge of potential allergens. The aim of this study was to investigate allergens in ophthalmic medicaments in New Zealand.

HEK-omics: The promise of omics to optimize HEK293 for recombinant adeno-associated virus (rAAV) gene therapy manufacturing.

Gene therapy is poised to transition from niche to mainstream medicine, with recombinant adeno-associated virus (rAAV) as the vector of choice. However, robust, scalable, industrialized production is required to meet demand and provide affordable patient access, which has not yet materialized. Closing the chasm between demand and supply requires innovation in biomanufacturing to achieve the essential step change in rAAV product yield and quality.

Forensic psychiatry in Turkiye.

Turkiye, with its origins in an enduring civilisation rooted in preceding Turkish states from ancient and medieval eras, possesses its own firmly established legal traditions. Legislation concerning to the mentally ill was introduced post the French Revolution in the Ottoman Empire and underwent reforms with the advent of Turkiye's modern Republic in 1923, led by Mustafa Kemal Atatürk. This remains an ongoing process of enhancement, despite the absence of a well-established mental health law.

Past, present and future global mangrove primary productivity.

Mangrove productivity is crucial for the global carbon cycle, yet previous research has mostly focused on small-scale temporal changes or static global patterns, with limited investigation into global or regional temporal trends. This study used existing data on mangrove leaf litter to model mangrove Net Primary Productivity (NPP) on a monthly timescale from 1980 to 2094 across global regions defined by the Marine Ecoregions of the World framework. The models showed a slight global decrease in NPP of approximately 1.