Publications by authors named "H J Hufnagel"
The accurate diagnosis of central serous chorioretinopathy (CSC) and its distinction from differential diagnoses is crucial for effective patient counseling and treatment. This is achieved through a targeted patient history and multimodal imaging, which distinguish CSC from other ocular diseases also characterized by subretinal fluid and changes in the retinal pigment epithelium. In this article we identify the key differential diagnoses of CSC and illustrate the characteristic differential diagnostic features of each disease.
View Article and Find Full Text PDF[Stress and other risk factors in central serous chorioretinopathy-A myth?].
Ophthalmologie
January 2025
Since the initial description of central serous chorioretinopathy (CSC) by von Graefe in 1866, various risk factors for this condition have been described and discussed. In addition to established factors, such as the use of corticosteroids, psychosomatic factors, particularly stress, have increasingly come into focus in the literature. Studies have shown that psychological stress and emotional stressors not only impair well-being but also trigger physiological responses that could increase the risk of CSC.
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- The study aimed to analyze the types and amounts of quality information requested by the FDA and EMA for biosimilar applications, focusing on Chemistry, Manufacturing, and Control data.
- Analysis of queries from seven biosimilars revealed that the majority targeted drug substance manufacture, control, and product development, with notable differences in query proportions between the two regulatory authorities.
- Findings emphasize the importance of manufacturing and control topics, highlighting the need for robust scientific and technical content to meet regulatory expectations for biosimilar approvals.
Background: Central serous chorioretinopathy (CSC) has frequently been associated with increased stress levels as well as an increased prevalence of other psychiatric conditions. This study used standardized psychometric scores to assess stress, depression and anxiety levels of CSC patients and compared them to controls without retinal disease ("healthy") and with branch retinal vein occlusion (BRVO).
Methods: Monocentric, longitudinal case control study on consecutive CSC patients seen at a tertiary referral center.
Introduction: The German Registry of central serous chorioretinopathy (CSC) collects data on CSC patients in a nationwide multicenter approach to analyze epidemiology, risk factors, clinical presentations, as well as diagnosis and treatment patterns.
Methods: In this multicenter cohort study, patients with CSC were enrolled in nine tertiary referral centers in Germany between January 2022 and June 2023. After consenting to the study, demographic data, risk factors, reported symptoms, best-corrected visual acuity (BCVA), funduscopic findings, disease severity, and diagnostic and treatment decisions were recorded and analyzed.