Structural inequality linked to brain volume and network dynamics in aging and dementia across the Americas.

Structural inequality, the uneven distribution of resources and opportunities, influences health outcomes. However, the biological embedding of structural inequality in aging and dementia, especially among underrepresented populations, is unclear. We examined the association between structural inequality (country-level and state-level Gini indices) and brain volume and connectivity in 2,135 healthy controls, and individuals with Alzheimer's disease and frontotemporal lobe degeneration from Latin America and the United States.

The Clinical Assessment of Eccentric and Concentric Stepping Kinetics has Utility in Older African American Men with Knee Arthritis.

Introduction: Stair navigation is physically demanding for individuals with knee osteoarthritis and may result in movement asymmetries that can be quantified using kinetic analysis and force-time parameters. Thus, the purpose of this cross-sectional study was to determine if kinetic force-time parameter asymmetries are present in individuals with knee osteoarthritis and associated with functional outcomes.

Methods: Forty-six older male veterans (61.

Land surface temperature and socioeconomic residential segregation in the Metropolitan Zone of San Luis Potosí, Mexico.

Economic growth and urban sprawl in territorial systems produce an uneven distribution of infrastructure and services. This creates residential areas with high capital gains that are affordable only for the middle and upper classes. For lower-income groups, the only options are depressed urban areas with limited infrastructure.

Drug repurposing for neglected and zoonotic diseases.

Globalization and climate change have intensified the need to address the marginalization of R&D for neglected and zoonotic diseases. We propose that drug repurposing, using enabling technologies such as artificial intelligence, can address this need at a lower cost than de novo R&D processes.