A multi-molecular beam/infrared reflection absorption spectroscopy apparatus for probing mechanisms and kinetics of heterogeneously catalyzed reaction from ultrahigh vacuum to near-ambient pressure conditions.

A novel multi-molecular beam/infrared reflection absorption spectroscopy (IRAS) apparatus is described, which was constructed for studying mechanisms and kinetics of heterogeneously catalyzed reactions following a rigorous surface science approach in the pressure range from ultrahigh vacuum (UHV, 1 × 10-10 mbar) to near-ambient pressure (NAP, 1000 mbar) conditions. The apparatus comprises a preparation chamber equipped with standard surface science tools required for the preparation and characterization of model heterogeneous catalysts and two reaction chambers operating at different pressure ranges: in UHV and in the variable pressure range up to NAP conditions. The UHV reaction chamber contains two effusive molecular beams (flux up to 1.

The membrane domains of mammalian adenylyl cyclases are lipid receptors.

The biosynthesis of cyclic 3',5'-adenosine monophosphate (cAMP) by mammalian membrane-bound adenylyl cyclases (mACs) is predominantly regulated by G-protein-coupled receptors (GPCRs). Up to now the two hexahelical transmembrane domains of mACs were considered to fix the enzyme to membranes. Here, we show that the transmembrane domains serve in addition as signal receptors and transmitters of lipid signals that control Gsα-stimulated mAC activities.

Field curvature reduction in miniaturized high numerical aperture and large field-of-view objective lenses with sub 1 µm lateral resolution.

In this paper the development of a miniaturized endoscopic objective lens for various biophotonics applications is presented. While limiting the mechanical dimensions to 2.2 mm diameter and 13 mm total length, a numerical aperture of 0.

Genome-guided purification of high amounts of the siderophore ornibactin and detection of potentially novel burkholdine derivatives produced by Burkholderia catarinensis 89T.

Aim: The increased availability of genome sequences has enabled the development of valuable tools for the prediction and identification of bacterial natural products. Burkholderia catarinensis 89T produces siderophores and an unknown potent antifungal metabolite. The aim of this work was to identify and purify natural products of B.