Publications by authors named "H J Freitag"
Article Synopsis
- The study investigates the effectiveness of immunoadsorption (IA) treatment on post-COVID myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) patients, focusing on those with elevated β2 adrenergic autoantibodies.
- Patients underwent five IA sessions and showed significant improvement in physical functioning, fatigue, and other symptoms over six months, with 70% responding positively to the treatment.
- The findings suggest that IA could be a beneficial therapy for alleviating symptoms in post-COVID ME/CFS patients, indicating a possible link between autoimmunity and the condition.
Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a debilitating multisystemic disease characterized by a complex, incompletely understood etiology. To facilitate future clinical and translational research, a multicenter German ME/CFS registry (MECFS-R) was established to collect comprehensive, longitudinal, clinical, epidemiological, and laboratory data from adults, adolescents, and children in a web-based multilayer-secured database. Here, we present the research protocol and first results of a pilot cohort of 174 ME/CFS patients diagnosed at two specialized tertiary fatigue centers, including 130 (74.
View Article and Find Full Text PDFThe continuous emergence of multidrug-resistant bacterial pathogens poses a major global healthcare challenge, with Klebsiella pneumoniae being a prominent threat. We conducted a comprehensive study on K. pneumoniae's antibiotic resistance mechanisms, focusing on outer membrane vesicles (OMVs) and polymyxin, a last-resort antibiotic.
View Article and Find Full Text PDFArticle Synopsis
- Post-COVID syndrome (PCS) includes various symptoms lasting over 3 months after COVID-19, with fatigue being a major issue.
- A study of 144 female patients found that those meeting the criteria for myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) reported more severe symptoms and disability compared to other PCS patients.
- Hand grip strength (HGS) was used as a measurable indicator of physical function, revealing that while all PCS patients had impaired HGS, only those with ME/CFS showed a significant correlation between HGS and the severity of other key symptoms, indicating a different underlying mechanism for fatigue in this group.