Publications by authors named "H J Frederiksen"
Chronic lymphocytic leukemia (CLL) is characterized by the accumulation of B cells due to constitutive B-cell receptor (BCR) signaling, leading to apoptosis resistance and increased proliferation. This study evaluates the effects of the Bruton Tyrosine Kinase (BTK) inhibitor ibrutinib on the molecular composition, clonality, and kinetics of B cells during treatment in CLL patients. Employing a multi-omics approach of up to 3.
View Article and Find Full Text PDFChronic hemolysis potentially elevates the risk of gallstones in several types of congenital red blood cell (RBC) disorders. However, the magnitude of the risk is unknown. We investigate the risk of gallstone disease in congenital RBC disorder patients, compared with general population comparators.
View Article and Find Full Text PDFObjectives: This study investigated healthcare utilisation in general practice and hospitals in the 2 years preceding a diagnosis of haematological cancer and the association with patient pathways.
Methods: The nationwide register-based cohort study included 12 994 patients diagnosed with leukaemia, multiple myeloma and lymphoma in 2014-2018 and 10 matched references. Patient pathways were analysed in unplanned routes (acute admission up to 1 month's prior diagnosis) and elective routes (other routes, e.
Article Synopsis
- The study investigates the potential links between maternal phthalate exposure during pregnancy and reproductive health outcomes in their teenage daughters, particularly focusing on hormone levels and reproductive anatomy indicators.
- Subtle associations were found between the levels of phthalate metabolites in prenatal samples and reproductive hormone levels (LH and IGF-1) and uterine volume measured 16 years later.
- The research involved 317 teenage daughters from a longitudinal study, assessing their development through hormonal analysis and ultrasound to evaluate ovarian and uterine health.*
Background: Female minipuberty is characterized by complex dynamics of circulating reproductive hormones, while the relationship between ovarian and uterine morphology and reproductive hormones remains to be elucidated.
Aim: To investigate the association between reproductive hormones and ovarian as well as uterine morphology by transabdominal ultrasound (TAUS) at minipuberty.
Methods: Secondary analysis from The Copenhagen Analgesic Study (COPANA) (ClinicalTrials.