Publications by authors named "H J F Helmerhorst"
Article Synopsis
- The study investigates the use of folate receptor (FR)-targeted PET/CT imaging with [F]fluoro-PEG-folate for better preoperative assessment in advanced-stage epithelial ovarian cancer (EOC), aiming to enhance selection for cytoreductive surgery (CRS) and reduce unnecessary procedures.
- It evaluates the safety and tolerability of [F]fluoro-PEG-folate through vital sign monitoring and adverse event recording, along with quantifying disease burden using the Peritoneal Cancer Index (PCI) score from imaging and surgical findings.
- The study was halted early after including eight patients, revealing that while [F]fluoro-PEG-folate was safe
Purpose: To describe the pharmacokinetic properties of the [F]fluoro-polyethylene glycol(PEG)-folate radiotracer in PET/CT imaging of patients with advanced stage epithelial ovarian cancer (EOC).
Procedures: In five patients with advanced EOC (FIGO stage IIIB/IIIC, Fédération Internationale de Gynécologie et d'Obstétrique), a 90-min dynamic PET acquisition of the pelvis was performed directly after i.v.
Objectives: Deferred consent enables research to be conducted in the ICU when patients are unable to provide consent themselves, and there is insufficient time to obtain consent from surrogates before commencing (trial) treatment. The aim of this study was to evaluate how former ICU patients reflect on their participation in a study with deferred consent and examine whether their opinions are influenced by the quality of life (QoL) following hospital discharge.
Design: Survey study by questionnaire.
Supplemental oxygen is widely administered to ICU patients, but appropriate oxygenation targets remain unclear. This study aimed to determine whether a low-oxygenation strategy would lower 28-day mortality compared with a high-oxygenation strategy. This randomized multicenter trial included mechanically ventilated ICU patients with an expected ventilation duration of at least 24 hours.
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