Publications by authors named "H J Duivenvoorden"
Breast cancer is the second most common human malignancy and is a major global health burden. Heparanase (HPSE) has been widely implicated in enhancing the development and progression of solid tumours, including breast cancer. In this study, the well-established spontaneous mammary tumour-developing MMTV-PyMT murine model was utilised to examine the role of HPSE in breast cancer establishment, progression, and metastasis.
View Article and Find Full Text PDFUnderstanding how cancer cells interact with the surrounding microenvironment early in breast cancer development can provide insight into the initiation and progression of invasive breast cancers. The myoepithelial cell layer surrounding breast ducts acts as a physical barrier in early breast cancer, preventing cancer cells from invading the surrounding stroma. Changes to the expression profile and properties of myoepithelial cells have been implicated in progression to invasive carcinoma.
View Article and Find Full Text PDFIntratumoral administration of the Toll-like receptor 7/8 agonist 3M-052 enhances interferon-driven tumor immunogenicity and suppresses metastatic spread in preclinical triple-negative breast cancer.
Clin Transl Immunology
September 2020
Article Synopsis
- Loss of type I interferon (IFN) signaling in tumors is linked to faster metastatic progression, which is why researchers are exploring alternative intratumoral agents like TLR 7/8 agonist 3M-052 for treating triple-negative breast cancer (TNBC).
- This study found that 3M-052 not only reduces tumor growth but also enhances the immune response, particularly through the activation of T-cells and dendritic cells, ultimately leading to reduced metastasis to the lungs.
- The findings suggest that using TLR agonists in immunotherapy could be a promising strategy to activate the immune system in tumors and prevent future metastases in TNBC patients.
Article Synopsis
- Scientists discovered that some cancer cells can "take a break" before they start growing and causing problems, especially in a type of prostate cancer that doesn't respond to regular treatment.
- They found that these sleepy cancer cells are helped by signals in the tumor, and when these signals go away, the cancer can grow more aggressively.
- By fixing those signals, they were able to make the cancer cells more visible to the immune system, which helped the body fight off the cancer better and stop its growth in the bone.
Patients diagnosed with triple negative breast cancer (TNBC) have an increased risk of rapid metastasis compared to other subtypes. Predicting long-term survival post-chemotherapy in patients with TNBC is difficult, yet enhanced infiltration of tumor infiltrating lymphocytes (TILs) has been associated with therapeutic response and reduced risk of metastatic relapse. Immune biomarkers that predict the immune state of a tumor and risk of metastatic relapse pre- or mid-neoadjuvant chemotherapy are urgently needed to allow earlier implementation of alternate therapies that may reduce TNBC patient mortality.
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