Lipoxin-Induced Phenotypic Changes in CD115LY6C Monocytes TAM Precursors Inhibits Tumor Development.

During tumor development, the spleen acts as an extra-medullar reservoir of LY6C inflammatory monocytes, which can migrate toward tumor to differentiate into tumor-associated macrophage (TAMs), renewing the TAM population. In the tumor microenvironment, pro-inflammatory macrophages (M1) acquire anti-inflammatory and pro-tumor (M2) characteristics favoring tumor development. We previously demonstrated that lipoxins, a family of pro-resolving lipid mediators, restored the cytotoxic M1-like properties of TAMs.

CO adsorption at nitrogen-doped carbons prepared by KCO activation of urea-modified coconut shell.

This article reports on the synthesis and characterization of porous nitrogen-doped carbons synthesized by carbonization of coconut shell followed by urea modification and KCO activation. The as-synthesized samples were carefully characterized by various techniques. This series of samples demonstrate high CO uptake at 1bar, up to 3.

Factors affecting the direct mineralization of CO2 with olivine.

Olivine, one of the most abundant minerals existing in nature, is explored as a CO2 carbonation agent for direct carbonation of CO2 in flue gas. Olivine based CO2 capture is thermodynamically favorable and can form a stable carbonate for long-term storage. Experimental results have shown that water vapor plays an important role in improving CO2 carbonation rate and capacities.

Reaction kinetics of CO2 carbonation with Mg-rich minerals.

Due to their low price, wide availability, and stability of the resulting carbonates, Mg-rich minerals are promising materials for carbonating CO(2). Direct carbonation of CO(2) with Mg-rich minerals reported in this research for the first time could be considerably superior to conventional liquid extraction processes from an energy consumption perspective due to its avoidance of the use of a large amount of water with high specific heat capacity and latent heat of vaporization. Kinetic models of the reactions of the direct CO(2) carbonation with Mg-rich minerals and within simulated flue gas environments are important to the scale-up of reactor designs.

Potent mGluR5 antagonists: pyridyl and thiazolyl-ethynyl-3,5-disubstituted-phenyl series.

We report the synthesis of four series of 3,5-disubstituted-phenyl ligands targeting the metabotropic glutamate receptor subtype 5: (2-methylthiazol-4-yl)ethynyl (1a-j,), (6-methylpyridin-2-yl)ethynyl (2a-j), (5-methylpyridin-2-yl)ethynyl (3a-j,), and (pyridin-2-yl)ethynyl (4a-j,). The compounds were evaluated for antagonism of glutamate-mediated mobilization of internal calcium in an mGluR5 in vitro assay. All compounds were found to be full antagonists and exhibited low nanomolar to subnanomolar activity.