Publications by authors named "H J Clarke"
Cannabidiol (CBD), a bicyclic non-psychoactive cannabinoid biosynthesized by Cannabis spp. of plants, has attracted significant interest in the past decade due to its therapeutic properties. In 2018, the US FDA approved Epidiolex®, a CBD-based drug for the treatment of two rare epileptic seizure disorders.
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- This study examines the effectiveness of oral ketamine as a pain reliever after major spine surgery, noting its potential to reduce reliance on opioids, which have problematic side effects.
- Conducted at Toronto Western Hospital, the trial was randomized and placebo-controlled involving 35 adult patients undergoing lumbar spine surgery.
- While there were no significant differences in overall recovery or pain scores between ketamine and placebo groups, those receiving ketamine used fewer opioids post-surgery and reported some benefits such as improved recovery.
Article Synopsis
- The study explores the role of glycerol-3-phosphate phosphatase (G3PP) in male fertility, highlighting its crucial expression in the testis and sperm, especially during spermatogenesis.
- Researchers found that male mice lacking G3PP (cG3PP-KO) are infertile due to dysfunctional sperm with poor motility and increased oxidative stress, while a tamoxifen-inducible version (icG3PP-KO) maintained some fertility due to a small number of normal sperm.
- The results suggest that G3PP is vital for sperm function and health, as its absence leads to abnormal sperm production and metabolism, impacting overall male fertility.
Background: Negative perceptions of psilocybin and challenges of participant enrollment may represent barriers to conducting a randomized controlled trial examining psilocybin for chronic neuropathic pain.
Aim: Prior to trial initiation, we aimed to examine patient attitudes toward the trial via a prospective preference assessment.
Methods: Twenty-six patients with chronic neuropathic pain participated in a prospective preference assessment comprising quantitative (survey) and qualitative (interview) components.