Publications by authors named "H Isozaki"
Article Synopsis
- * Higher levels of miR-505-5p/-3p are found in MES-GSCs compared to other types of glioma stem cells and normal brain tissue; lowering these miRNAs affects cell behavior.
- * Targeting miR-505-5p/-3p leads to increased cell growth and differentiation, while reducing ability to invade and resist the drug temozolomide, indicating these miRNAs help regulate important cellular functions by repressing AUF1 expression.
Backgrounds: To the best of our knowledge, there are no reports of proteomic analysis for the identification of unknown proteins involved in resistance to anaplastic lymphoma kinase (ALK) inhibitors. In this study, we investigated the proteins involved in resistance to alectinib, a representative ALK inhibitor, through proteomic analysis and the possibility of overcoming resistance.
Methods: An ALK-positive lung adenocarcinoma cell line (ABC-11) and the corresponding alectinib-resistant cell line (ABC-11/CHR2) were used.
Article Synopsis
- Duodenal stump fistula (DSF) is a serious complication that can occur after gastrectomy, with no standard treatment guidelines.
- A case study is presented where a patient with advanced gastric cancer developed DSF post-surgery, leading to reoperation due to severe complications like sepsis.
- The patient ultimately recovered after thorough surgical intervention and the use of a continuous drainage system, highlighting effective management strategies for DSF.
Aim: The usefulness of 5-aminolevulinic acid (5-ALA) fluorescence-assisted surgery for maximum resection of malignant gliomas has been established. However, its usefulness when combined with endoscopic surgery for deep-seated tumors has not been well established. In this study, whether 5-ALA photodynamic diagnosis (PDD) is feasible and useful for endoscopic surgery was investigated.
View Article and Find Full Text PDF