Publications by authors named "H Iskender"
Objectives: This experiment was carried out to investigate the protective effects of curcumin (CUR) on testicular damage induced by the valproic acid (VPA) administration.
Materials And Methods: Male Wistar-Albino rats (n=28, 250-300 g) were randomly divided into four groups: Control (1 ml saline, oral), VPA (500 mg/kg, IP), CUR (200 mg/kg, oral), or VPA+CUR (500 mg/kg, VPA, IP plus 200 mg/kg CUR, oral). The treatments were applied for 14 days.
Article Synopsis
- Valproic acid (VPA) is an effective antiepileptic medication but can also cause toxic effects on brain, kidney, and liver tissues due to oxidative stress and inflammation.
- Curcumin, a natural antioxidant found in ginger, exhibits antibacterial and anti-inflammatory properties and was tested for its protective effects against VPA toxicity in a study involving male Wistar-Albino rats.
- Results showed that curcumin could effectively reduce the oxidative stress and inflammation caused by VPA, suggesting it may help mitigate the side effects of this drug in patients who use it for epilepsy.
Background: Pandemics, such as COVID-19, have the potential to adversely affect children's development due to a variety of negative factors at the level of children, families, and services. In this study the effect of the pandemic on the cognitive, language and motor development of premature babies who are among the most vulnerable group, were evaluated.
Methods: The study included 236 premature infants who were followed at Hacettepe University Department of Developmental Pediatrics.
Objectives: Neuropathy, retinopathy, and nephropathy, known as the triopathy of diabetes, are the consequences of microvascular complications of diabetes. The present study aimed to investigate the potential protective effects of oleanolic acid (OA) administration against diabetic nephropathy considering biochemical and histopathological parameters.
Materials And Methods: The rats with fasting blood glucose levels of 200 mg/dl and above were considered diabetic after induction of diabetes via injecting STZ.
Objectives: Diabetes mellitus (DM) is an important public health problem all over the world, considering its complications and increasing prevalence. Oleanolic acid (OA) has anti-diabetic property via modulating glucose metabolism and acting as 5'-adenosine monophosphate (AMP)-activated protein kinase (AMPK) / Sirtuin-1 (SIRT-1) activator and Interleukin 6 (IL-6) / Nuclear factor kappa B (NF-κB) inhibitor. This research questioned if the OA treatment amliorates the hepatic inflammatory profile in the diabetic rats.
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