Publications by authors named "H Ishiguro"
This study employs Conversation Analysis to create a recursive model that improves the quality of human-robot interaction. Our research goal is to create a dialogue robot that offers pleasant experiences for users, so they are willing to engage in repeated interactions in daily lives. While there has been dramatic progress in the performance of dialogue robots, there has been less attention to the importance of users' interactional experience compared to the "specs" of the dialogue system.
View Article and Find Full Text PDFCybernetic avatars integrate physical and virtual avatars to enhance human capabilities in diverse scales and contexts.
View Article and Find Full Text PDFChemical modifications of cellular RNAs play key roles in gene expression and host defense. The cap-adjacent ,2'--dimethyladenosine (mAm) is a prevalent modification of vertebrate and viral mRNAs and is catalyzed by the newly discovered methyltransferase PCIF1. However, its role in gene expression remains unclear due to conflicting reports on its effects on mRNA stability and translation.
View Article and Find Full Text PDFArticle Synopsis
- This study compared the effectiveness of two surgical procedures, anterior spinal fusion (ASF) and posterior cervical foraminotomy (PCF), in helping patients recover motor function after surgery for cervical spondylotic radiculopathy (CSR).
- A total of 227 patients were evaluated, with 106 focusing specifically on those with upper-limb motor deficits, and their recovery was monitored for at least 12 months post-surgery.
- Results indicated that while the overall recovery rates were similar (74% for ASF and 86% for PCF), the PCF group recovered motor function significantly faster at 3, 6, and 12 months compared to the ASF group, suggesting PCF may be the better option for quicker recovery
Article Synopsis
- Neoadjuvant treatment with microtubule inhibitors (MTIs) for triple negative breast cancer (TNBC) is not well understood, prompting a study that analyzed tumor samples to correlate genetic mutations with treatment response.
- The study found that tumors with high homologous recombination deficiency (HRD) and specific mutations (like BRCA2) had higher rates of complete response to MTIs like eribulin and paclitaxel.
- Transcriptomic profiling highlighted FGFR2 downregulation as a critical gene linked to treatment response and identified a significant pathway (glycan degradation) that could influence resistance to these therapies in TNBC patients.*