Metabolomic Analysis of Nicotine-Induced Metabolic Disruptions and Their Amelioration by Resveratrol.

This study investigates the metabolic disruptions caused by nicotine (NIC) exposure, with a particular focus on amino acid and lipid metabolism, and evaluates resveratrol (RSV) as a potential protective agent. Mice were divided into four groups: control (CON), NIC-exposed, NIC + RSV-treated, and RSV-only. NIC exposure resulted in significant weight loss, elevated glucose levels, altered lipid profiles, and organ damage, particularly in the liver and kidneys.

Venous Thromboembolism (VTE) Prophylaxis on Discharge Following Major Cancer Surgery in the Abdomen: Improving Compliance With National Guidelines.

Background Venous thromboembolism (VTE) prophylaxis in hospitalized patients, particularly those undergoing abdominal surgery for cancer, is critical to reducing the incidence of deep vein thrombosis (DVT) and pulmonary embolism (PE). Despite increased awareness, ensuring appropriate VTE prophylaxis post-discharge remains challenging. The National Institute for Health and Care Excellence (NICE) guidelines recommend prolonged prophylaxis in specific cases, yet compliance on discharge often falls short.

Metabolomic Analysis and Biochemical Profiling of Cadmium-Induced Metabolic Impairment and Its Amelioration by Resveratrol.

Exposure to heavy metals, particularly cadmium (Cd), poses significant health risks because of their toxic effects and potential for bioaccumulation in living organisms. This study examined the biochemical and metabolomic changes induced by Cd exposure in an animal model via advanced liquid chromatography with tandem mass spectrometry (LC-MS/MS) and biochemical assays to reveal significant disruptions in lipid and amino acid metabolism as well as alterations in key metabolic pathways. Cd exposure led to significant weight loss, hyperglycemia, and insulin resistance, indicating its role in metabolic disorders such as diabetes.

Mixtures of toxic organic micropollutants compromise the safety of water resources in urban agglomerations in low- and medium-income countries: The example of Lahore, Pakistan.

Contamination of water resources with mixtures of organic micropollutants (OMP) including pesticides, pharmaceuticals, and industrial chemicals is a serious threat to aquatic organisms and human health. Long-term exposure to such pollutants may cause detrimental effects even at very low concentrations. Water resources in urban agglomerations in low- and medium-income countries may be under particular pressure due to high population densities, significant industrial activities, and limited water treatment and management resources.