Dithienoarsinines: stable and planar π-extended arsabenzenes.

Stable planar dithienoarsinines were synthesized and structurally characterized. These compounds exhibit monomeric structures in the solution and solid states, avoiding dimerization, even in the absence of steric protection. They exhibited high global aromaticity with 14 or 22π-electron systems.

Evaluation of dipole moment of polyhedral oligomeric silsesquioxane compounds.

The aggregation state of polyhedral oligomeric silsesquioxane (POSS) within a polymer matrix plays a crucial role. Molecular interactions are key driving forces for aggregation, and one of the key physical parameters is the dipole moment (DPM). Quantum calculations such as density functional theory (DFT) calculations can be used to estimate the DPM.

MRTX1719, an MTA-cooperative PRMT5 Inhibitor, Induces Cell Cycle Arrest and Synergizes With Oxaliplatin and Gemcitabine for Enhanced Anticancer Effects.

Background/aim: MRTX1719 is a novel protein arginine methyltransferase 5 (PRMT5) inhibitor that targets the PRMT5-5'-Methylthioadenosine (MTA) complex called MTA-cooperative PRMT5 inhibitor. MRTX1719 acts specifically on methylthioadenosine phosphorylase (MTAP)-deficient cancer cells; however, its mechanism of action remains unclear. This study aimed to clarify the effects of MRTX1719 on the cell cycle and its synergistic effects with other anticancer drugs.

An ionic liquid containing arsonium cation.

Cations in ionic liquids (ILs) are typically derived from ammonium or phosphonium structures with long alkyl chains, and it is well established that the central atom significantly influences the properties of the resulting ILs. In this study, an arsonium-based IL, trihexylmethylarsonium bis(trifluoromethylsulfonyl)amide, was synthesized. The arsonium cation was found to contribute to lower viscosity and higher ionic conductivity, while maintaining sufficient stability compared to its phosphonium counterpart.