Factors affecting outcome of acquired comitant esotropia with restricted use of digital devices: ACEDD Study 3.

Objective: The objective of this study is to investigate factors associated with outcomes after 3 months of instructed usage of hand-held digital devices (DD) in patients with acquired comitant esotropia (ACE).

Methods And Analysis: This prospective multicentre observational study included patients with ACE, aged 5-35 years, who used DD within 1 year of onset and were followed up for clinical findings and instructed use of DD. The outcomes were classified into four groups: cured, improved, unchanged and worsened.

Clinical presentations of acquired comitant esotropia in 5-35 years old Japanese and digital device usage: a multicenter registry data analysis study.

Purpose: To describe clinical presentations of acquired comitant esotropia and digital device use in children, adolescents, and young adults without neurological problems.

Study Design: Multicenter prospective observational study.

Methods: Patients with acquired comitant esotropia, without intracranial diseases aged 5-35 years at the time of visit, who were seen at pre-registered facilities within 1 year of onset were enrolled.

Evaluation of an Integrin αβ Radiotracer, [F]F-FPP-RGD, for Monitoring Pharmacological Effects of Integrin α siRNA in the NASH Liver.

Purpose: Integrin α is a key regulator in the pathophysiology of hepatic fibrosis. In this study, we evaluated the potential utility of an integrin αβ positron emission tomography (PET) radiotracer, F-labeled cyclic arginine-glycine-aspartic acid penta-peptide ([F]F-FPP-RGD), for detecting hepatic integrin α and function in nonalcoholic steatohepatitis (NASH) model rats using integrin α siRNA.

Methods: NASH model rats were produced by feeding a choline-deficient, low-methionine, high-fat diet for 8 weeks.

Usefulness of F-FPP-RGD PET in pathophysiological evaluation of lung fibrosis using a bleomycin-induced rat model.

Purpose: Integrins α are key molecules in the pathogenesis of fibrosis in multiple organs. To assess the potential utility of integrin αβ imaging for idiopathic pulmonary fibrosis (IPF), we evaluated an F-FPP-RGD PET probe in a rat model of bleomycin-induced lung fibrosis.

Methods: Pulmonary fibrosis was induced by single intratracheal instillation of bleomycin (3 mg/rat).

Clinical findings of acute acquired comitant esotropia in young patients.

Purpose: This study aimed to identify the characteristics of acute acquired comitant esotropia (AACE) in young patients from a single institution; and clarify their relationship with the excess use of digital devices.

Study Design: Retrospective, observational.

Methods: We extracted the clinical charts of patients aged between 5 and 35 years who presented at the Hamamatsu University Hospital with AACE symptoms from January 1, 2015 to December 31, 2018.