Publications by authors named "H Ibrahim Tekin"
Purpose: Type 1 Diabetes (T1D) pathogenesis involves immune cells infiltrating pancreatic Islets of Langerhans, leading to T cell activation, beta cell destruction, and impaired insulin production. However, infiltration has a heterogenic nature that isn't described in detail, as not all islets are infiltrated. The aim of this study was to investigate if the observed heterogeneity is coupled to differences in immune and/or dysfunctional status of islets or exocrine cells, and if specific markers could elucidate mechanistic details of T1D pathogenesis.
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- Fluoroscopic examinations, such as ERCP and PTC, are essential for diagnosing hepatobiliary diseases but expose patients to significant radiation, prompting a need to better assess radiation doses to critical organs.
- The study used an Alderson RANDO phantom and Thermoluminescent Dosemeters to measure actual radiation exposure during these procedures, finding that PTC generally yields higher doses, particularly to the thyroid and spleen.
- Results highlight the necessity of evaluating the risks versus benefits of these procedures due to the notable radiation exposure, suggesting a preference for ERCP when minimizing radiation is necessary, and advocating for continued improvements in medical imaging to enhance patient safety.
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- Chronic kidney disease (CKD) is a common and impactful health issue worldwide, but traditional lab methods for assessing serum creatinine are slow and costly, limiting timely diagnoses.
- This study presents a new compact system that uses an integrated heater and smartphone technology for rapid, accurate serum creatinine measurement, employing the Jaffe method within a microreservoir chip.
- The innovative, low-cost device (approximately $87) allows for decentralized testing, potentially improving CKD management and accessibility, particularly in areas lacking advanced laboratory facilities.
Radiosensitization with metallic nanoparticles under MeV proton beams: local dose enhancement.
Radiat Environ Biophys
November 2024
In addition to specific dosimetric properties of protons, their higher biological effectiveness makes them superior to X-rays and gamma radiation, in radiation therapy. In recent years, enrichment of tumours with metallic nanoparticles as radiosensitizer agents has generated high interest, with several studies attempting to confirm the efficacy of nanoparticles in proton therapy. In the present study Geant4 Monte Carlo (MC) code was used to quantify the increased nanoscopic dose deposition of 50 nm metallic nanoparticles including gold, bismuth, iridium, and gadolinium in water upon exposure to 5, 25, and 50 MeV protons.
View Article and Find Full Text PDFBreast-conserving surgery (BCS) followed by radiotherapy is preferred for early-stage breast cancer because its survival rate is equivalent to that of mastectomy. Achieving negative surgical margins in BCS is crucial to minimize the risk of recurrence. Intraoperative ultrasound (IOUS) enhances surgical accuracy, but its efficacy is operator dependent.
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