A new species of Schrank (Lepidoptera, Plutellidae) from the Andes of northern Chile.

Background: The moth genus Schrank, 1802 (Lepidoptera, Plutellidae) includes 26 described species. In addition to the diamondback moth, (Linnaeus, 1758), which is an important and widely distributed pest of cruciferous crops, only two species have been previously recorded in Chile, both with distribution ranges restricted to the southern temperate rainforests.

New Information: sp.

 sp. nov., the first South American representative of the micromoth genus Braun (Lepidoptera, Gracillariidae, Lithocolletinae).

The micromoth (Lepidoptera, Gracillariidae, Lithocolletinae) from the arid highlands of the western slope of the Andes of northern Chile is described and illustrated. Larvae construct bulged leaf mines on the shrub Phil. (Asteraceae).

Predicting clinical outcomes from off-target receptor interactions using Secondary Intelligence™.

Adverse effects due to off-target activity can be predicted by careful comparison of the relationship between expected plasma concentration and off-target activity of the test compound with that of reference drugs targeting that receptor for their therapeutic efficacy. The ratio between plasma concentration (unbound) and the K at the receptor is a surrogate measure reflecting receptor occupancy. Where data are available for reference drugs, we have curated and evaluated this at 100 receptors, 72 of which can involve both negative and positive modulations by drugs: a total of 172 'receptor modulations'.

Cardiorespiratory Fitness From Cardiopulmonary Exercise Testing Is a Comprehensive Risk-stratifying Tool in Liver Transplant Candidates.

Background: Cardiovascular disease and physical decline are prevalent and associated with morbidity/mortality in liver transplant (LT) patients. Cardiopulmonary exercise testing (CPX) provides comprehensive cardiopulmonary and exercise response assessments. We investigated cardiorespiratory fitness (CRF) and cardiac stress generated during CPX in LT candidates.