Depot-specific acetylation profiles of adipose tissues-therapeutic targets for metabolically unhealthy obesity.

Background: Adipose tissue plays a critical role in the development of metabolically unhealthy obesity (MUO), with distinct adipose depots demonstrating functional differences. This study aimed to investigate the unique characteristics of subcutaneous (SA) and visceral adipose tissue (VA) in MUO.

Methods: Paired omental VA and abdominal SA samples were obtained from four male patients with MUO and subjected to Four-Dimensional Data Independent Acquisition (4D-DIA) proteomic and lysine acetylation (Kac) analyses.

Fine-tuning gibberellin improves rice alkali-thermal tolerance and yield.

Soil alkalinization and global warming are predicted to pose major challenges to agriculture in the future, as they continue to accelerate, markedly reducing global arable land and crop yields. Therefore, strategies for future agriculture are needed to further improve globally cultivated, relatively high-yielding Green Revolution varieties (GRVs) derived from the SEMIDWARF 1 (SD1) gene. Here we propose that precise regulation of the phytohormone gibberellin (GA) to optimal levels is the key to not only confer alkali-thermal tolerance to GRVs, but also to further enhance their yield.

Alkali and sulfate effects on mechanical properties and microscopic mechanisms of slag and fly ash geopolymers.

Aiming at the problem that it is difficult to realize low-cost, high-performance and large-scale utilization of cementitious materials prepared from bulk solid wastes, this paper constructs a set of composite cementitious system based on alkaline activation of slag and fly ash (FA) by calcium carbide slag (CCS) and synergistic activation of sodium sulfate (NaSO) as a chemical dopant. The influence of factors such as solid waste type, mixing ratio, and NaSO content on the mechanical properties of composite cementitious systems was investigated by assessing compressive strength and analyzing microstructure using XRD, SEM-EDS, and FTIR. The test results indicate that CCS and NaSO exert significant influences on the strength of the composite cementitious system.

Comparison of clinical and virological features in pediatric and adult dengue cases at Insein General Hospital during Myanmar's 2022 dengue season.

Background: Myanmar is one of the countries in Southeast Asia where serious dengue outbreaks occur and Yangon is among the regions with the highest number of cases in the country. Many infections including dengue are common in Yangon during the rainy season, and co-infections may also occur. Adults are more likely than children to experience co-infections of dengue and other diseases.

First-Line Mobocertinib Versus Platinum-Based Chemotherapy in Patients With Exon 20 Insertion-Positive Metastatic Non-Small Cell Lung Cancer in the Phase III EXCLAIM-2 Trial.

Purpose: Mobocertinib is an oral epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor that targets exon 20 insertion (ex20ins) mutations in non-small cell lung cancer (NSCLC). This open-label, phase III trial (EXCLAIM-2: ClinicalTrials.gov identifier: NCT04129502) compared mobocertinib versus platinum-based chemotherapy as first-line treatment of ex20ins+ advanced/metastatic NSCLC.