Publications by authors named "H Hustinx"
Routine ABO blood group typing of apparently healthy individuals sporadically uncovers unexplained mixed-field reactions. Such blood group discrepancies can either result from a haematopoiesis-confined or body-wide dispersed chimerism or mosaicism. Taking the distinct clinical consequences of these four different possibilities into account, we explored the responsible cause in nine affected individuals.
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- ALX148 is a new CD47 blocking agent being tested for treating advanced tumors, but it can interfere with blood compatibility testing.
- The study involved testing plasma from patients treated with ALX148 to see how it affected routine blood tests, revealing false positives in certain antibody screening tests.
- Using soluble CD47 or high-affinity SIRPα can eliminate these false positives, ensuring accurate results without overlooking important antibodies.
Article Synopsis
- A 64-year-old male experienced a febrile non-hemolytic transfusion reaction (FNHTR) 20 minutes after receiving a red blood cell unit.
- The patient had undergone unrelated donor hematopoietic stem cell transplantation (HCT) 20 days earlier, with a minor ABO mismatch.
- Prior to this, he had multiple transfusions for plasma cell myeloma, but did not report any reactions or alloimmunization.
Article Synopsis
- Spontaneous changes in the Rh blood group were observed in two unrelated, apparently healthy individuals with hematologic disorders, showing unexpected mixed red cell phenotypes associated with the c antigen (RH4).
- Their blood samples displayed a mix of c-positive and c-negative cells, despite no history of transfusions and no evidence of chimerism.
- Genetic analysis revealed partial loss of heterozygosity in specific chromosomal regions, indicating a complex mechanism involving chromosome deletion and duplication that could explain their unique Rhc phenotype and suggest somatic mosaicism in their hematopoietic systems.