Publications by authors named "H Huopio"
Aim: This study aimed to assess the cognitive development of individuals with congenital hypothyroidism.
Methods: Using hospital records, we identified 180 patients with congenital hypothyroidism born between 1980 and 2018 in Turku and Kuopio University Hospital catchment areas. Cognitive development was evaluated in 22 adults (7 males and 15 females) and 20 children (8 males and 12 females) using age-specific Wechsler Intelligence Scales.
Article Synopsis
- The study aimed to assess how primary congenital hypothyroidism (CH) affects quality of life, education level, and socioeconomic status (SES) among patients.
- Data were collected from Finnish registers and patient records; results showed no significant differences in education, marital status, or SES compared to matched controls.
- While CH patients integrated socially like their peers, their health-related quality of life was notably lower, with many reporting that the condition impacted their daily lives.
Comorbidity in Congenital Hypothyroidism-A Nationwide, Population-based Cohort Study.
J Clin Endocrinol Metab
November 2023
Context: Patients with congenital hypothyroidism (CH) are affected more often than the general population by other chronic diseases and neurological difficulties.
Objective: The aim of this nationwide population-based register study was to investigate the incidence of congenital malformations, comorbidities, and the use of prescribed drugs in patients with primary CH.
Methods: The study cohort and matched controls were identified from national population-based registers in Finland.
Health-related quality of life in boys with constitutional delay of growth and puberty.
Front Endocrinol (Lausanne)
December 2022
Article Synopsis
- Constitutional delay of growth and puberty (CDGP) is a common cause of delayed puberty in healthy boys, often leading to psychosocial issues that may warrant medical treatment.* -
- A study involving 22 boys with CDGP compared the effects of treatments (aromatase inhibitor letrozole vs. testosterone) on their health-related quality of life (HRQoL) over 12 months, using a validated 16D assessment tool.* -
- Results showed that while CDGP boys had similar overall HRQoL scores to their peers initially, they were less satisfied with their physical appearance; after treatment, their appearance satisfaction significantly improved, aligning their HRQoL with that of age-matched boys.*
Introduction: Newborn screening of congenital hypothyroidism (CH) has enabled early treatment with levothyroxine (LT4), ensuring normal growth and development. The initial LT4 dose recommendation has increased over decades. We evaluated whether the increased LT4 dosing influenced thyroid-stimulating hormone (TSH) and thyroxine (fT4) concentrations, growth, or treatment-related symptoms.
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