Somatostatin mode of action on gastric acid secretion in dogs.

The aim of the present study was to investigate the mode of the inhibitory effect of somatostatin on gastric acid secretion. This was done in Heidenhain-pouch dogs studying the effect of somatostatin on cumulative dose response curves of pentagastrin, carbachol and histamine. Somatostatin inhibited gastric secretion after all three stimuli, with decreasing potency against carbachol, pentagastrin and histamine.

The effect of pressure changes inside the antrum on lower esophageal sphincter (LES) pressure in man and dog.

The pressure change inside the lower esophageal sphincter (LES) in response to pressure changes inside the antrum was investigated in man and in dogs with antral pouches. In dogs with innervated antral pouches a pressure increase of 20 cm H2O inside the antrum produced an increase in LES pressure of 14 +/- 7 mm Hg, whereas an antral pressure of 80 cm H2O caused a decrease of 26 +/- 12 mm Hg in LES pressure (x +/- SD). Truncal vagotomy abolished LES response to the various antral pressures.

Motilin effects on gastrointestinal motility and lower esophageal sphincter (LES) pressure in dogs.

Natural porcine motilin induces phasic contractions of the lower esophageal sphincter in dogs. These contractions are related to gastric contractions, which have the characteristics of interdigestive-motility patterns. Duodenal alkalinization produces an insignificant LES pressure increase after 5 minutes.

The effect of intravenous infusion of synthetic human gastrin-I on lower esophageal sphincter (LES) pressure in the dog and its relation to gastrin level.

To demonstrate the relation between gastrin level and lower esophageal sphincter (LES) pressure, experiments with intravenous infusions of synthetic human gastrin-I (SHG-I) were performed in anaesthetized dogs. The results show that infusions with 5 mug-kg-1-h-1 SHG-I have an initially increasing effect on LES pressure but produce unphysiologically high gastrin blood levels. Physiological levels of gastrin were measured only using an infusion dose of 0.

The motor-stimulating effect of natural motilin on the lower esophageal sphincter fundus, antrum and duodenum in dogs.

Natural motilin was investigated for its effect on gastrointestinal motor activity in anesthetized dogs. In doses starting from 10 ng/kg as single injection and 100 ng/kg-h as intravenous infusion, motilin induced phasic pressure changes in the lower esophageal sphincter (LES) and in the lumen of the fundus, antrum, and duodenum. Tachyphylaxis was seen in 6 out of 10 dogs.