Calcium (Ca) fluxes at mitochondria-ER contact sites (MERCS) are a new target of senolysis in therapy-induced senescence (TIS).

Therapy-induced senescence (TIS) alters calcium (Ca²⁺) flux and Mitochondria-ER Contact Sites (MERCS), revealing critical vulnerabilities in senescent cells. In this study, TIS was induced using Doxorubicin and Etoposide, resulting in an increased MERCS contact surface but a significant reduction in ER-mitochondria Ca²⁺ flux. Mechanistically, TIS cells exhibit decreased expression of IP3R isoforms and reduced interaction between type 1 IP3R and VDAC1, impairing Ca²⁺ transfer.

Natural infection with Trypanosoma cruzi and feeding habits of Triatominae (Hemiptera: Reduviidae) from the state of Durango, Mexico.

Chagas disease is a chronic and systemic condition caused by the protozoan Trypanosoma cruzi, acquired via abrasions or wounds on the skin or mucous membranes, through contact with feces or urine of hematophagous bugs belonging to the family Reduviidae, subfamily Triatominae. Many regions in Mexico are endemic for Chagas disease, but entomological and parasitological data are still limited. This study identified the incidence of natural infection with T.

Wing geometric morphometrics is effective to separate sand fly species (Diptera, Psychodidae, Phlebotominae) related with leishmaniasis transmission in Mexico.

Nearly 32 % of sand fly species recorded in Mexico are related to Leishmania transmission. A correct morphological identification of sand flies is essential to improve epidemiological and control strategies. Wing geometric morphometrics (GM) has proven to be a complementary tool for classical taxonomy, allowing us to explore variations in structure and shape between species.

FIRST STATE AND NATIONAL RECORDS OF CULICOIDES DEBILIPALPIS AND CULICOIDES REEVESI IN CHIHUAHUA, MEXICO.

In July 2022, adult female Culicoides were collected from San Buenaventura (54 specimens) and Urique (3 specimens) in Chihuahua, Mexico. Culicoides reevesi and Culicoides debilipalpis were new records for the state, with C. reevesi also being a first for Mexico.

Effective Compression and a Minimally Invasive Rail Plate to Optimize Bone Transport in Distraction Osteogenesis: New Concepts.

Background: Bone transport in distraction osteogenesis is an effective, well-known procedure. However, bone compression is an aspect of this technique for which there is no objective information. The lack of direct bone compression measurements may result in a lack of uniformity in the bone transport process, which can result in its ineffective application and may be contributing to its underutilization.