A multidimensional assessment of in-host fitness costs of drug resistance in the opportunistic fungal pathogen Candida glabrata.

Drug-resistant microbes typically carry mutations in genes involved in critical cellular functions and may therefore be less fit under drug-free conditions than susceptible strains. Candida glabrata is a prevalent opportunistic yeast pathogen with a high rate of fluconazole resistance (FLZR), echinocandin resistance (ECR), and multidrug resistance (MDR) relative to other Candida. However, the fitness of C.

Evaluation of antioxidant activity and heavy metals content in licorice ( L.) growing wild in Armenia.

In this study, for the first time an analysis of the metal content in extracts obtained from licorice roots grown in the forests of five different regions in Armenia was conducted. Our findings indicated that the concentrations of metals in the extracts did not exceed the permissible limits set by regulatory standards. Furthermore, we investigated the quantitative composition of flavonoids, tannins, and anthocyanins in the licorice roots, which had not been previously studied.

Overlooked petites are echinocandin tolerant, induce host inflammatory responses, and display poor fitness.

is a major fungal pathogen, which is able to lose mitochondria and form small and slow-growing colonies, called "petite." This attenuated growth rate has created controversies and questioned the clinical importance of petiteness. Herein, we have employed multiple omics technologies and mouse models to critically assess the clinical importance of petite phenotype.

Overlooked petites are echinocandin tolerant, induce host inflammatory responses, and display poor fitness.

Unlabelled: Small colony variants (SCVs) are relatively common among some bacterial species and are associated with poor prognosis and recalcitrant infections. Similarly, - a major intracellular fungal pathogen - produces small and slow-growing respiratory-deficient colonies, termed "petite." Despite reports of clinical petite .

Multiplexed target enrichment of coding and non-coding transcriptomes enables studying spp. infections from human derived samples.

The study of transcriptomic interactions between host and pathogens in conditions is challenged by the low relative amounts of the pathogen RNA. Yeast opportunistic pathogens of the genus can cause life-threatening systemic infections in immunocompromised patients, and are of growing medical concern. Four phylogenetically diverse species account for over 90% of infections, and their specific interactions with various human tissues are still poorly understood.