Publications by authors named "H Horikawa"
Although multiple studies suggest that ionizing radiation can induce bystander effects (radiation-induced bystander effect, RIBE) in cultured cell lines, it is still unclear whether RIBE is evolutionarily conserved in invertebrates. In this study, we investigated the frequency of cell death of unirradiated starfish (Patiria pectinifera) oocytes co-cultured with oocytes irradiated with X rays (0, 2 and 4 Gy). We observed increased frequencies of cell death determined by morphological abnormality and TUNEL-positive cells in unirradiated oocytes co-cultured with oocytes irradiated with 2 Gy or 4 Gy oocytes.
View Article and Find Full Text PDFSince nail psoriasis restricts the patient's daily activities, therapeutic intervention based on reliable and reproducible evaluation is critical. The Nail Psoriasis Severity Index (NAPSI) is a validated scoring tool, but its usefulness is limited by interobserver variability. This study aimed to develop a reliable and accurate NAPSI scoring tool using deep learning.
View Article and Find Full Text PDFArticle Synopsis
- - The study investigates the link between rare copy number variations (CNVs) in synaptic genes and bipolar disorder (BD) in a Japanese population, using genome hybridization techniques on nearly 2,000 BD patients and 2,760 controls.
- - Results indicate a strong association between the RNF216 gene and BD, with significant findings also related to postsynaptic membrane components, suggesting these genetic factors contribute to BD risk.
- - The findings enhance understanding of BD's genetic underpinnings, highlighting the importance of CNVs in gene regions that may influence the disorder's development.
Article Synopsis
- Eosinophilic granulomatosis with polyangiitis (EGPA) is a complex condition that complicates diagnosis due to its diverse symptoms, as illustrated by a 59-year-old woman with asthma and sinusitis who presented with rare skin blisters and nerve issues.
- Medical examinations showed elevated eosinophils, a specific antibody related to neutrophils, and signs of small vessel inflammation, leading to the diagnosis of EGPA.
- Treatment with glucocorticoids and cyclophosphamide resulted in significant improvement, highlighting the importance of recognizing unusual skin lesions for early diagnosis and intervention to prevent serious complications.