Hypertonic Saline Induces Host Protective Immune Responses against Infection in Mice.

Hypertonic saline (HTS) resuscitation can enhance immune responses against various pathogens, however, the effect of HTS on brucellosis is yet to be defined. In this study, we found that HTS inhibited infection in mice by augmenting Th1 immunity. HTS treatment enhanced the serum cytokines production and the expression of nitric oxide synthase (NOS2) and nuclear factor kappa B (NF-ĸB) p50 and p65, crucial anti- effectors in splenocytes.

Enhancement of mycobacterial pathogenesis by host interferon-γ.

The cytokine IFNγ is a principal effector of macrophage activation and immune resistance to mycobacterial infection; however, pathogenic mycobacteria are capable of surviving in IFNγ-activated macrophages by largely unknown mechanisms. In this study, we find that pathogenic mycobacteria, including M. bovis BCG and M.

Intracellular growth of Brucella is mediated by Dps-dependent activation of ferritinophagy.

Bacteria of the genus Brucella cause brucellosis, one of the world's most common zoonotic diseases. A major contributor to Brucella's virulence is the ability to circumvent host immune defense mechanisms. Here, we find that the DNA-binding protein Dps from Brucella is secreted within the macrophage cytosol, modulating host iron homeostasis and mediating intracellular growth of Brucella.

Effects of chronic crude oil exposure on the fitness of polar cod (Boreogadus saida) through changes in growth, energy reserves and survival.

Climate models predict extended periods with sea-ice free Arctic waters during the next decade, which will allow more shipping activity and easier access to petroleum resources. Increased industrial activities raise concerns about the biological effects of accidental petroleum release on key species of the Arctic marine ecosystem, such as the polar cod (Boreogadus saida). This study examines effects on physiological traits related to the fitness of adult polar cod, such as growth, survival, and lipid parameters.