Publications by authors named "H Honma"
Background: The anticancer activity and radiosensitizing effect of Auranofin, an an-tirheumatic and an approved gold metallic drug, have been investigated from multiple perspectives. In this study, the action of the new gold complex compound TPN-Au(I)-MM4 was compared with that of auranofin.
Methods: The inhibitory effect of 10 μM and 50 μM concentrations on cell proliferation was investigated using the human colon cancer cell lines HCT116 and SW480.
Primary intracranial sarcoma (PIS) is a rare and aggressive pediatric brain tumor, which is partially associated with DICER1 mutant. Although the molecular genetic characteristics of this tumor have previously been investigated, novel therapeutic targets remain unclear. Further, the lack of faithful preclinical models has hampered the development of novel therapeutic strategies.
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- - The study investigated serum salicylic acid (SA) levels in children with Kawasaki disease (KD) after they were treated with moderate doses of acetylsalicylic acid (ASA).
- - Out of 142 patients analyzed, median SA levels decreased from 22 µg/mL during the acute phase to 15 µg/mL during recovery, with a notable percentage of patients having levels below detectable limits.
- - The findings showed that serum SA levels varied widely and were not linked to responsiveness to intravenous immunoglobulin (IVIG) treatment.
Article Synopsis
- Prostaglandin E-major urinary metabolite (PGE-MUM) is highlighted as a key biomarker that indicates the cytokine profile in patients.
- A 14-year-old boy with severe ulcerative colitis didn't respond to traditional treatments like steroids and infliximab, requiring consideration of surgery.
- Elevated PGE-MUM levels suggested a specific cytokine profile, leading to successful treatment with mirikizumab, which resulted in the patient achieving remission.
Lung cancer is the leading cause of cancer-related morbidity and mortality worldwide. The initial treatment of lung cancer depends on the definition of the tumor type and its staging. The most common treatment is chemotherapy, and the first-line treatment is a combination of carboplatin and paclitaxel.
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