Publications by authors named "H Hoelz"
Article Synopsis
- Pediatric patients with eosinophilic esophagitis (EoE) can experience ongoing inflammation and symptoms even after histologic improvement, indicating deeper molecular issues.
- A study involving 247 esophageal biopsy samples identified persistent molecular changes in EoE, including 17 dysregulated genes and 6 proteins that remained altered even in inactive stages of the disease.
- The findings reveal that while some molecular markers normalize in deep remission, others, particularly periostin (POSTN), continue to be elevated, indicating a need for further understanding of EoE's molecular landscape for better treatment strategies.
Background: Limited approval of second-line treatments in pediatric inflammatory bowel disease (pIBD) necessitates optimized use of infliximab (IFX) with proactive therapeutic drug monitoring (TDM). We investigated whether early combo-therapy with an immunomodulator (IMM) provides additional benefit.
Methods: In the retrospectively reviewed medical records of all children treated with IFX and proactive TDM between 2013 and 2022, IMMearly (IMM ≤3 months since IFX start) was evaluated against IMMother/no (late/short or no IMM) over follow-up of 3 to 60 months.
Article Synopsis
- Exclusive enteral nutrition (EEN) is effective at inducing remission in pediatric Crohn's disease but leads to high relapse rates once regular diets are resumed.
- The study involved collecting fecal samples from pediatric patients on EEN, which were processed into FMT capsules after pathogen safety screening.
- Results showed that while FMT capsule generation was mostly successful, issues like a high pathogen burden and low microbial diversity in the samples suggest that using this method for long-term maintenance therapy in pediatric Crohn's disease may not be feasible.
Acute bronchiolitis is a common disease of infants affecting the small airways. Rarely, acute bronchiolitis may occur in adolescents and adults. Here, we present four unrelated adolescent patients with severe clinical presentation and unique CT imaging with extensive tree-in-bud pattern, representing a rare clinical phenotype of acute diffuse panbronchiolitis.
View Article and Find Full Text PDFIntroduction: Next generation sequencing (NGS) with customized gene panels is a helpful tool to identify monogenic epilepsy syndromes. The number of genes tested within a customized panel may vary greatly. The aim of the present study was to compare the diagnostic yield of small (<25 kb) and large (>25 kb) customized epilepsy panels.
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