Publications by authors named "H Hodemaekers"
Article Synopsis
- * In a study involving 132 T2D cases and 132 matched controls, researchers found that certain CpG sites exhibit different DNAm trajectories, indicating accelerated aging in those who develop T2D compared to healthy individuals.
- * The findings suggest specific DNAm changes occur up to 10 years before T2D diagnosis, pointing to the need for more research on biomarkers of biological aging to predict age-related diseases.
Resorbable tissue fillers for aesthetic purposes can induce severe complications including product migration, late swelling, and inflammatory reactions. The relation between product characteristics and adverse effects is not well understood. We hypothesized that the degree of cross-linking hyaluronic acid (HA) fillers was associated with the occurrence of adverse effects.
View Article and Find Full Text PDFThere is an increased awareness that the use of animals for compound-induced developmental neurotoxicity (DNT) testing has limitations. Animal-free innovations, especially the ones based on human stem cell-based models are pivotal in studying DNT since they can mimic processes relevant to human brain development. Here we present the human neural progenitor test (hNPT), a 10-day protocol in which neural progenitor cells differentiate into a neuron-astrocyte co-culture.
View Article and Find Full Text PDFBackground: Humans are exposed to combinations of chemicals. In cumulative risk assessment (CRA), regulatory bodies such as the European Food Safety Authority consider dose addition as a default and sufficiently conservative approach. The principle of dose addition was confirmed previously for inducing craniofacial malformations in zebrafish embryos in binary mixtures of chemicals with either similar or dissimilar modes of action (MOAs).
View Article and Find Full Text PDFBackground: Ensuring consistency of tetanus neurotoxin (TeNT) production by could help to ensure consistent product quality in tetanus vaccine manufacturing, ultimately contributing to reduced animal testing. The aim of this study was to identify RNA signatures related to consistent TeNT production using standard and non-standard culture conditions.
Methods: We applied RNA sequencing (RNA-Seq) to study gene expression in small-scale batches under several culture conditions.