Publications by authors named "H Hiraga"
Background: A serum biomarker for diagnosing ulcerative colitis (UC) remains to be established. Although we recently reported an anti-integrin αvβ6 antibody (V6 Ab) for diagnosing UC with high sensitivity and specificity, no large-scale validation study exists. This study aimed to validate the diagnostic value of V6 Ab for UC using a nationwide multicenter cohort study.
View Article and Find Full Text PDFLight sensing is a critical function in most organisms and is mediated by photoreceptor proteins and phototransduction. Although most nematodes lack eyes, some species exhibit phototaxis. In the nematode Caenorhabditis elegans, the unique photoreceptor protein Cel-LITE-1, its downstream G proteins, and cyclic GMP (cGMP)-dependent pathways are required for phototransduction.
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- - The study evaluated factors impacting the effectiveness of second-generation colon capsule endoscopy (CCE) in diagnosing colorectal issues, focusing on patient demographics, cleansing methods, and detection rates of polyps or tumors.
- - Among 1,006 patients across 44 Japanese hospitals, findings revealed that younger age, male sex, and proper preparation significantly improved the success of CCE, with an overall detection rate of around 89-92% for larger colorectal tumors.
- - CCE had a low retention rate and was generally well-accepted, with 63% of patients preferring CCE for future colonoscopies, reinforcing its safety and effectiveness when bowel preparation is adequate.
Article Synopsis
- * It aims to determine if having surgery followed by three courses of adjuvant chemotherapy is as effective as the standard approach of chemotherapy followed by surgery and then more chemotherapy.
- * The trial is a large, randomized phase III study that began in November 2022 and seeks to confirm that the new treatment method is not inferior regarding overall survival rates.