Publications by authors named "H Hessel"

Article Synopsis
  • * A total of 4,532 NIPT tests were performed, with 125 indicating an increased risk for trisomies 13, 18, 21, and sex chromosome abnormalities; further testing revealed other chromosomal issues not covered by standard NIPT.
  • * The findings showcase the ability of NIPT to detect complex chromosomal abnormalities, such as segmental duplications and mosaicism, underscoring its potential for genome-wide screening of copy number variations. *
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Article Synopsis
  • Tertiary Lymphoid Structures (TLS) are linked to better cancer patient survival and responses to immunotherapies, but their effectiveness can vary based on size, composition, and maturation.
  • A study on Non-Small Cell Lung Carcinoma (NSCLC) used a multiplex immunofluorescent panel to analyze tumor samples from 406 patients, focusing on specific immune cell types within TLS.
  • The analysis led to a TLS scoring system that identified key features predictive of patient outcomes, showing correlations with other cancer biomarkers but not with PD-L1 status.
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Emerging adulthood has changed dramatically in the last 30 years, in part due to the widespread adoption of communication technology. Despite studies showing that youth in the United States are communicating with extended family using technology, research on online interactions with non-parental relatives is lacking. Framed by intergenerational solidarity theory, this study identifies subgroups of U.

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Upper current limits (C-levels) are sometimes extremely increased over time since this procedure can enhance speech perception. It should be clarified if a larger amount of electrical stimulation is tolerated by the remaining peripheral and central auditory pathway. An animal electrode array was inserted in mechanically deafened guinea pigs.

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The identification of new tumor biomarkers for patient stratification before therapy, for monitoring of disease progression, and for characterization of tumor biology plays a crucial role in cancer research. The status of these biomarkers is mostly scored manually by a pathologist and such scores typically, do not consider the spatial heterogeneity of the protein's expression in the tissue. Using advanced image analysis methods, marker expression can be determined quantitatively with high accuracy and reproducibility on a per-cell level.

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