Publications by authors named "H Herrema"
Sex differences in the gut microbiome have been examined previously, but results are inconsistent, often due to small sample sizes. We investigated sex and menopausal differences in the gut microbiome in a large multi-ethnic population cohort study, including 5166 participants. Using machine learning models, we revealed modest associations between sex and menopausal status, and gut microbiota composition (AUC 0.
View Article and Find Full Text PDFArticle Synopsis
- Bacteria can host foreign genetic elements like plasmids and bacteriophages, which were once thought to be separate but now show significant interaction.
- Phage-plasmids (P-Ps) have unique functions, acting as both plasmids that exist independently and phages that can infect and destroy bacteria, allowing for the spread of genetic traits such as antibiotic resistance.
- The review highlights the need for more research on the ecological roles and prevalence of P-Ps in microbial communities, despite existing studies on their characteristics and functions.
Article Synopsis
- Maternal stress during the postpartum period affects the nutrient composition and microbiome of human milk (HM), potentially impacting early development and mental health outcomes for infants.
- A study involving high-stress (HS) and control groups analyzed HM microbiome changes, revealing distinct differences in bacterial composition, particularly showing HS mothers had altered levels of certain bacteria like reduced Streptococcus and increased Staphylococcus.
- The findings indicate a strong correlation between maternal stress and changes in the HM microbiome, suggesting these alterations could influence infant gut colonization and overall health, necessitating further research on their implications.
Kinetics of imidazole propionate from orally delivered histidine in mice and humans.
NPJ Biofilms Microbiomes
November 2024
Imidazole Propionate (ImP), a gut-derived metabolite from histidine, affects insulin signaling in mice and is elevated in type 2 diabetes (T2D). However, the source of histidine and the role of the gut microbiota remain unclear. We conducted an intervention study in mice and humans, comparing ImP kinetics in mice on a high-fat diet with varying histidine levels and antibiotics, and assessed ImP levels in healthy and T2D subjects with histidine supplementation.
View Article and Find Full Text PDF