Publications by authors named "H Hendrikse"
Androgen receptor-targeting agents, particularly enzalutamide, show promise in enhancing prostate cancer diagnostic and therapeutic strategies by modulating prostate-specific membrane antigen (PSMA). A retrospective clinical cohort study investigated 9 men with metastatic castration-resistant prostate cancer on enzalutamide. PSMA PET/CT scans were obtained before and after enzalutamide initiation to assess PSMA expression changes.
View Article and Find Full Text PDFAssessment of fully quantitative and simplified methods for analysis of [Ga]Ga-FAPI-46 uptake in patients with pancreatobiliary cancer using LAFOV PET/CT.
Eur J Nucl Med Mol Imaging
March 2025
Article Synopsis
- The study aimed to validate simpler methods for measuring [Ga]Ga-FAPI-46 uptake by comparing them to comprehensive pharmacokinetic modeling.
- Ten patients with pancreatobiliary cancer participated in a 90-minute dynamic PET/CT scan, and various methods, including plasma-input tissue-compartment models, were used to assess the uptake of the compound in lesions.
- The results indicated that image-based target-to-whole blood ratio (TBR) and mean standardized uptake values (SUVmean) at 60-70 minutes post-injection are effective and reliable for quantifying [Ga]Ga-FAPI-46 uptake.
A field campaign in the Vallunden lagoon in the Van Mijenfjorden on Spitsbergen was conducted to gather data on sea ice restoration by artificial flooding. Sea ice thickening was initiated by pumping sea water from below the first-year sea ice onto the surface without removing the covering snow layer. Part of the data was collected by four thermistor strings, two radiation sensors, and one anemometer.
View Article and Find Full Text PDFArticle Synopsis
- The study explored the use of Hardware-in-the-Loop (HiL) techniques for simulating offshore structures subjected to dynamic ice loads, addressing the limitations of traditional modeling methods.
- Analysis of 204 HiL simulations showed that this method provided reliable performance, with minimal errors even when varying key factors like structural models and ice types.
- Issues arose in testing with warm model ice and scaling for harsh conditions due to system instability, but improved performance was noted when the physical prototype interacted directly with the model ice, suggesting a beneficial coupling effect.
Upregulation of prostate-specific membrane antigen (PSMA) in neovasculature has been described in glioblastoma multiforme (GBM), whereas vasculature in nonaffected brain shows hardly any expression of PSMA. It is unclear whether PSMA-targeting tracer uptake on PET is based on PSMA-specific binding to neovasculature or aspecific uptake in tumor. Here, we quantified uptake of various PSMA-targeting tracers in GBM and correlated this with PSMA expression in tumor biopsy samples from the same patients.
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