Publications by authors named "H Helgeland"
Mechanisms regulating the gene expression program at different hypoxia severity levels in patient tumors are not understood. We aimed to determine microRNA (miRNA) regulation of this program at defined hypoxia levels from moderate to severe in prostate cancer. Biopsies from 95 patients were used, where 83 patients received the hypoxia marker pimonidazole before prostatectomy.
View Article and Find Full Text PDFPrevious studies suggest that subjective distress in children with functional neurological disorder (FND) is associated with stress-system dysregulation and modulates aberrant changes in neural networks. The current study documents illness-promoting psychological processes in 76 children with FND (60 girls and 16 boys, aged 10.00-17.
View Article and Find Full Text PDFChronic fatigue syndromes: real illnesses that people can recover from.
Scand J Prim Health Care
December 2023
Article Synopsis
- The 'Oslo Chronic Fatigue Consortium' challenges the belief that chronic fatigue syndromes, like post-covid conditions, are untreatable diseases, offering a more hopeful perspective for patients.
- The consortium suggests that symptoms are linked to the brain's response to various biological, psychological, and social factors rather than being tied to a specific illness, and emphasizes how perception of these symptoms can influence their persistence.
- They advocate for a shift in approach from prolonged rest and isolation to encouraging patients to understand their symptoms differently and gradually resume normal activities, while also promoting open discussions that include recovered patients' insights.
Background And Purpose: The biology behind individual hypoxia levels in patient tumors is poorly understood. Here, we used radiogenomics to identify associations between magnetic resonance imaging (MRI)-based hypoxia levels and biological processes derived from gene expression data in prostate cancer.
Materials And Methods: For 85 prostate cancer patients, MRI-based hypoxia images were constructed by combining diffusion-weighted images reflecting oxygen consumption and supply.