Publications by authors named "H Helander"
The role of high-mobility group box 1 (HMGB1) in the pathogenesis of febrile seizures (FSs) is unclear. In our controlled follow-up study, we compared serum levels of HMGB1 (s-HMGB1) in the same individuals after the first FS, during febrile episodes without a FS, after recurrent FS, during healthy periods after FS, and between patients and controls. In all, 122 patients with FSs were included in the final analysis, including 18 with recurrent FSs with a complete follow-up protocol.
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- Intellectual disability (ID) covers a broad range, with mild cases being part of the general intelligence distribution and severe cases often linked to specific genetic disorders.
- A study of a large cohort in Northern Finland revealed that while a small percentage of mild ID is due to Finnish-enriched recessive variants, dominant variants have a more significant role in both mild and severe cases.
- Analysis showed that both rare and common genetic variants contribute to ID, with their combined effects being more predictive of ID status than each type alone.
The morphology of the small intestinal mucosa is reflected by the degree of stimuli. Previous studies have come to different conclusion about whether the mucosa is equally symmetrical. The aim of the study is to investigate whether there are structural differences in the mesenteric versus antimesenteric mucosa in mice, rats, and humans.
View Article and Find Full Text PDFBackground And Aims: The conditions for jejunal glucose absorption in healthy subjects have not been thoroughly studied. In this study we investigated differences in enlargement factor, as well as of the surface enterocytes and mitochondria, comparing 2 weeks of high-carbohydrate (HCD) versus high-fat diets (HFD). We also measured the ketogenesis rate-limiting enzyme 3-hydroxy-3-methylglutaryl-CoA synthase (HMGCS2) in relation to jejunal mitochondria.
View Article and Find Full Text PDFBackground: The role of cytokines in the pathogenesis of febrile seizures (FSs) is unclear, and information regarding cytokine production outside of FS episodes is scarce.
Methods: In our controlled follow-up study of patients with FSs, we compared the levels of 12 serum cytokines after the patients' first FSs, during febrile episodes without FSs, after recurrent FSs, during healthy periods after FSs, and between patients and controls.
Results: Two-hundred fifty-one patients with first FS participated in the study, of whom 17 (mean age 1.