Publications by authors named "H Hawkes"

Article Synopsis
  • Atopic dermatitis (AD) involves a Th2 inflammatory response damaging the skin, and there's a strong link between this condition and a specific strain of bacteria, A2-165, known for producing butyrate.
  • Researchers have determined the 3D structure of an important enzyme, 3-hydroxybutyryl-CoA dehydrogenase (A2HBD), using advanced X-ray techniques, revealing its interactions with key molecules like acetoacetyl-CoA and NAD.
  • The study highlights significant conformational changes in A2HBD when substrates bind, particularly noting how specific residues contribute to substrate recognition and the enzyme's overall catalytic activity.
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Kamut sprouts (KaS) contain several biologically active compounds. In this study, solid-state fermentation using and was used to ferment KaS (fKaS-ex) for 6 days. The fKaS-ex showed a 26.

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In this article, a novel cryotherapy approach using a uniform, controlled, and consistent in vivo application of liquid nitrogen (LN) spray as a Metered Cryospray (MCS) process is described. Although MCS may be used for many potential clinical applications, this paper focuses on the development that led to the controlled and consistent delivery of radial LN cryogen spray in order to generate a uniform circumferential effect and how the amount of MCS can be adapted to specifically ablate targeted diseases within a patient's lumen such as an airway or esophagus.

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Background And Purpose: To assess, through systematic review, distinctive or common clinical signs of autosomal dominant cerebellar ataxias (ADCAs), also referred to as spinocerebellar ataxias (SCAs) in genetic nomenclature.

Methods: This was a structured search of electronic databases up to September 2012 conducted by two independent reviewers. Publications containing proportions or descriptions of ADCA clinical features written in several languages were selected.

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Background: The thioredoxin system maintains redox balance through the action of thioredoxin and thioredoxin reductase. Thioredoxin regulates the activity of various substrates, including those that function to counteract cellular oxidative stress. These include the peroxiredoxins, methionine sulfoxide reductase A and specific transcription factors.

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