Positive association of large alcohol intake per occasion with vision-threatening severe diabetic retinopathy or diabetic macular edema in Japanese men with type 2 diabetes.

Objective: Differing from the overall consumption of alcohol, whether consuming large quantities of alcohol per drinking occasion is associated with higher risk of developing severe diabetic retinopathy remains unknown.

Methods: We examined whether the quantity per drinking occasion (QPO), including a large QPO, and the combinations of the frequency of alcohol consumption (FAC) and QPO were associated with higher risk of developing severe diabetic retinopathy or diabetic macular edema (DME) using adjusted Cox models. Severe diabetic retinopathy or DME was designated as a vision-threatening treatment-required diabetic eye disease (TRDED).

Mechanical signaling through membrane tension induces somal translocation during neuronal migration.

Neurons migrate in a saltatory manner by repeating two distinct steps: extension of the leading process and translocation of the cell body. The former step is critical for determining the migratory route in response to extracellular guidance cues. In the latter step, neurons must generate robust forces that translocate the bulky soma against mechanical barriers of the surrounding three-dimensional environment.

Unidirectional reconnection of an inter-atrial epicardial connection with wide right atrial insertion site: a case report.

Background: The epicardial connections (ECs) via intercaval fibres connecting the right-sided pulmonary veins (PVs) and right atrium (RA) can preclude isolation of the right-sided PVs. Such ECs occasionally have a unidirectional conduction property.

Case Summary: A 62-year-old man was referred to our institution for catheter ablation of paroxysmal atrial fibrillation (PAF).

Decreasing electricity costs of clean room for cell products during non-operation.

Introduction: Cell processing facilities are susceptible to environmental bacteria and must maintain sterile environments to safeguard cell products. This process involves circulating air through high-efficiency particulate air (HEPA) filters, which incurs significant maintenance costs. While cost-reduction strategies have been explored in the semiconductor industry, validations specific to cell processing facilities remain unreported.