Publications by authors named "H HONGO"
Objective: To elucidate the mechanisms underlying diabetic osteoporosis, we conducted a comprehensive histological examination of the femora of Spontaneously Diabetic Torii-Lepr (SDT-fa/fa) rats, an established model of obesity-related type 2 diabetes.
Materials And Methods: Femora from 12 30-week-old male SDT-fa/fa rats and age-matched Sprague-Dawley (SD) rats (controls) were used for detailed histochemical analyses, including tartrate-resistant acid phosphatase (TRAP), cathepsin K, alkaline phosphatase (ALP), phosphoethanolamine/ phosphocholine phosphatase 1 (PHOSPHO1), dentin matrix protein (DMP)-1, matrix extracellular phosphoglycoprotein (MEPE), sclerostin, osteocalcin staining, silver impregnation, von Kossa staining, and micro-computed tomography (CT).
Results: Micro-CT and hematoxylin-eosin staining demonstrated significantly reduced trabecular bone volume in the femoral metaphyses of SDT-fa/fa rats.
Parathyroid hormone (PTH) is thought to induce remodeling-based bone formation by promoting osteoclastic activity, a process known as cellular coupling. Our research has shown that the frequency of PTH administration affects trabecular number and thickness. High-frequency PTH administration induced remodeling-based bone formation, while less frequent administration induced both remodeling-based and modeling-based bone formation.
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- The study investigates periventricular anastomosis (PA) aneurysms in Moyamoya disease (MMD), revealing that these aneurysms are rare but can significantly impact patient outcomes.* -
- Results show that having a PA aneurysm correlates with higher initial disability scores (mRS) and a higher likelihood of future hemorrhagic strokes, indicating it as a risk factor for adverse events.* -
- Advanced analysis techniques, like machine learning and principal component analysis, underscore the unique characteristics of hemorrhagic-onset aneurysms, suggesting that greater PA development increases the risk of aneurysm presence and complications.*
Article Synopsis
- Intracranial artery stenosis (ICAS) is linked to ischemic stroke, and the RNF213 p.Arg4810Lys genetic variant may play a role in this condition, particularly in patients who are asymptomatic.
- A study involving 139 patients showed that 25% carried the RNF213 variant, which was associated with higher rates of stenosis progression (25.7%) compared to non-carriers (8.7%) over an average follow-up of 58 months.
- The findings indicate that the RNF213 p.Arg4810Lys variant is significantly associated with increased risk of stenosis progression, suggesting different underlying mechanisms in vascular health that merit further research.
Background: The emergence of flow disruptors has brought a dynamic transition in the selection of treatment for middle cerebral artery (MCA) aneurysms, and the number of MCA aneurysms clipped is acceleratingly decreasing. Still, retreatment after endovascular treatment is still a dilemma, which may necessitate surgical clipping. It is all the more important to elucidate characteristics of MCA aneurysms that make clipping unfavorable.
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