Optimal Predilatation Treatment Before Implantation of a Magmaris Bioresorbable Scaffold in Coronary Artery Stenosis: The OPTIMIS Trial.

Background: Bioresorbable scaffolds (BRS) were developed to overcome limitations related to late stent failures of drug-eluting stents, but lumen reductions over time after implantation of BRS have been reported. This study aimed to investigate if lesion preparation with a scoring balloon compared with a standard noncompliant balloon minimizes lumen reduction after implantation of a Magmaris BRS assessed with optical coherence tomography and intravascular ultrasound.

Methods: Eighty-two patients with stable angina were randomized in a ratio of 1:1 to lesion preparation with a scoring balloon versus a standard noncompliant balloon before implantation of a Magmaris BRS.

Nitrogen doping turns carbonaceous materials into fast-reacting catalysts for reductive dechlorination.

Nitrogen (N) doping of biomass prior pyrolysis has been identified as an effective approach for enhancing biochar catalytic reactivity. However, high-temperature pyrolysis of N-rich biomass may produce N-devoid biochars with high reactivity, calling for attention to the true causes of the reactivity increases and the role of nitrogen. In this study, N-doped wheat straw biochar (N-BC) materials were produced using urea as N dopant and different pyrolysis conditions, and their catalytic reactivity assessed for the reduction of trichloroethylene (TCE) by green rust (GR), a layered Fe(II)Fe(III) hydroxide.

Genetic predisposition to altered blood cell homeostasis is associated with glioma risk and survival.

Glioma is a highly fatal and heterogeneous brain tumor with few known risk factors. Our study examines genetically predicted variability in blood cell indices in relation to glioma risk and survival in 3418 cases and 8156 controls. We find that increased platelet to lymphocyte ratio (PLR) confers an increased risk of glioma (odds ratio (OR) = 1.

Pipeline for development of acylated peptide based CGRP receptor antagonist with extended half-life for migraine treatment.

Migraine is a debilitating headache disorder. The disease has neurovascular origin and migraine attacks can be elicited by vasodilative neuropeptides such as alpha calcitonin gene-related peptide (αCGRP). Antagonizing CGRP actions in migraine patients has proven clinically efficient.

Novel digital leakage notification system can promote better stoma management routines: a multicentre clinical trial.

Background: Most people with a stoma are anxious about stoma-related leakage.

Aims: To investigate the impact of a novel digital leakage notification system on worry related to stoma leakage, and to evaluate the effect on overall stoma care management.

Method: A 12-week interventional, single-arm, multicentre study was conducted in the UK to evaluate the novel digital leakage notification system, including a telemedicine-based support service (=test product), as part of routine stoma care in patients with a recent stoma formation (ClinicalTrials.