Publications by authors named "H HACKL"
Background: Platelets are pivotal in maintaining vascular integrity, hemostasis, and immune modulation, with newly generated, immature platelets being the most responsive in fulfilling these tasks. Therefore, the immature platelet fraction provides insights into thrombopoiesis dynamics and clinical prognostication. However, it is currently unclear how immature platelet functions change in settings of acute thrombocytopenia.
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- The study investigates the limitations of immunotherapies in treating high-grade serous ovarian cancer (HGSOC) and explores the potential of combining immunotherapy with PARP inhibitors, emphasizing the roles of BRCAness and the tumor microenvironment in treatment response.
- Researchers performed detailed immunogenomic analyses and machine learning to identify a 24-gene signature predicting BRCAness, revealing high immune cell infiltration and an association with immunosuppressive cells in samples receiving combination therapies.
- Findings indicate that PARP inhibitors can activate immune-related pathways similarly to genetic BRCAness, and the team has developed a web app for analyzing ovarian cancer samples and providing a vulnerability score for patient stratification.
Cancer immunotherapies with antibodies blocking immune checkpoint molecules are clinically active across multiple cancer entities and have markedly improved cancer treatment. Yet, response rates are still limited, and tumour progression commonly occurs. Soluble and cell-bound factors in the tumour microenvironment negatively affect cancer immunity.
View Article and Find Full Text PDFBackground: Cystic neuroendocrine tumor liver metastases (NETLM) are rare and dynamics in the liquid compartment often misinterpreted as rapid progression, affecting selection for liver resection candidates. This study retrospectively evaluates surgical and oncologic outcomes in patients with cystic versus solid NETLM from small bowel and pancreatic primaries.
Methods: Between 2000 and 2020, 12 patients with cystic NETLM were identified among 464 patients who underwent >90 % tumor cytoreduction debulking hepatectomy at the Mayo Clinic.
In mammalian cells, glycerolipids are mainly synthesized using acyl-CoA-dependent mechanisms. The acyl-CoA-independent transfer of fatty acids between lipids, designated as transacylation reaction, represents an additional mechanism for lipid remodeling and synthesis pathways. Here, we demonstrate that human and mouse phospholipase A2 group IVD (PLA2G4D) catalyzes transacylase reactions using both phospholipids and acylglycerols as substrates.
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