Publications by authors named "H H Weinans"
Background: Addressing prosthetic joint infections poses a significant challenge within orthopedic surgery, marked by elevated morbidity and mortality rates. The presence of biofilms and infections attributed to () further complicates the scenario.
Objective: To investigate the potential of radioimmunotherapy as an innovative intervention to tackle biofilm-associated infections.
Objective: To study the association between various radiographic definitions of acetabular dysplasia (AD) and incident radiographic hip osteoarthritis (RHOA), and to analyze in subgroups.
Methods: Hips free of RHOA at baseline and with follow-up within 4-8 years were drawn from the World COACH consortium. The Wiberg center edge angle (WCEA), acetabular depth width ratio (ADR), and the modified acetabular index (mAI) were calculated.
Immune-involved cell communications have recently been introduced as key role players in the fate of mesenchymal stem cells in making bone tissue. In this study, a drug delivery system for bone (re)generation based on copper-doped mesoporous bioactive glass nanoparticles (BGNPs) was developed to codeliver copper as a biologically active ion and icariin as an anti-inflammatory agent. This design was based on temporal inflammation fluctuations from proinflammatory to anti-inflammatory during bone generation.
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- The study aimed to see if changes in MRI-defined bone marrow lesions (BMLs) and inflammatory markers are linked to cartilage loss in knees with osteoarthritis over 24 months.
- It analyzed data from 629 participants, finding that knees with no BMLs showed significantly less cartilage loss, while those with increasing BML size experienced more cartilage loss.
- The results suggest that preventing the growth of BMLs and worsening of Hoffa-synovitis could help reduce cartilage deterioration in osteoarthritis patients.
Autologous bone grafts are commonly used to repair defects in skeletal tissue, however, due to their limited supply there is a clinical need for alternatives. Synthetic ceramics present a promising option but currently lack biological activity to stimulate bone regeneration. One potential approach to address this limitation is the incorporation of immunomodulatory agents.
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