The effects of sound conditioning on gentamicin-induced vestibulocochlear toxicity in gerbils.

Objectives/hypothesis: Recent studies in animal models have shown via physiologic and histologic measures that the administration of exogenous antioxidants is protective against gentamicin-induced oto-vestibulo toxicity. In addition, studies have also shown that sound conditioning increases cochlear antioxidants. The objective of this study is to determine whether sound conditioning provides protection against gentamicin in the cochlear and/or vestibular system.

Direct round window application of gentamicin with varying delivery vehicles: a comparison of ototoxicity.

Objective: To evaluate patterns of ototoxic damage sustained from gentamicin applied directly to the round window in varying delivery vehicles.

Setting: The search for a reliable method of drug delivery to the inner ear continues. Vehicles such as Gelfoam, hyaluronic acid, and fibrin may allow for a more reproducible pattern of ototoxic damage.

Anatomic and morphometric changes to gerbil posterior cristas following transtympanic administration of gentamicin and streptomycin.

Many studies have sought to document ototoxic damage and to study repair and regeneration of mammalian vestibular sensory epithelia. However, linear density analysis of the sensory cells or use of methods that focus on detection of actin in the stereocilia and cuticular plates at the reticular lamina detect only the disappearance of "hair cells" as defined by a narrow set of criteria. The research presented here focuses on the effects of two ototoxic drugs (gentamicin and streptomycin).

Comparison of vestibular and cochlear ototoxicity from transtympanic streptomycin administration.

Hypothesis: The relative dose-related cochlear and vestibular ototoxicity produced by transtympanically injected streptomycin (SM) compared to that of gentamicin (GM) was assessed.

Background: Although SM, the first aminoglycoside used transtympanically, is thought to be selectively vestibulotoxic, it has been replaced by GM in current clinical use. Little experimental data exist that directly demonstrate the relative cochlear and vestibular ototoxicity resulting from transtympanic administration of SM compared to GM.