scRNA-seq reveals involvement of monocytes in immune response in SLE patients.

Background: Systemic Lupus Erythematosus (SLE) is a typical autoimmune disease characterized by a complex pathogenesis and a strong genetic predisposition. The study of inflammatory response in SLE monocytes is not very clear, and exploring the inflammatory factors of monocytes is beneficial to discover new diagnostic targets.

Results: Using scRNA-seq technology, we obtained the quantitative changes in circulating immune cells and various cellular immune metabolic profiles between SLE patients and healthy volunteers.

T cell receptor signaling pathway subgroups and construction of a novel prognostic model in osteosarcoma.

Background: T cell receptor (TCR) signaling pathway is closely related to tumor progress and immunotherapy. This study aimed to explore the clinical significance, prognosis, immune infiltration and chemotherapy sensitivity of TCR in osteosarcoma (OS).

Material And Methods: OS data were obtained from TARGET and GEO database.

Ultrasensitive ammonia sensor with excellent humidity resistance based on PANI/SnS heterojunction.

The analysis of human exhaled gas is crucial for early and noninvasive diagnosis. However, the complex composition and high-humidity of exhaled gas pose significant challenges to the application of gas sensors. This research focuses on the development of a chemiresistive ammonia sensor based on the polyaniline/tin disulfide (PANI/SnS) heterojunction, which is fabricated by hydrothermal and in-situ polymerization techniques.

RET-AREAL: a multi-center, real-world data analysis on the efficacy of pralsetinib in acquired RET fusion after resistance to EGFR/ALK-TKIs.

Pralsetinib demonstrated impressive improvement of survival in non-small cell lung cancer (NSCLC) patients harbored de novo RET fusion. However, the efficacy in patients with acquired RET fusion after resistance to EGFR/ALK-TKIs has only been reported on a case-by-case basis, and the strategy for overcoming the acquired RET fusion has not been fully investigated. This multicenter, real-world analysis enrolled 32 patients with unresectable NSCLC harbored acquired RET fusion after resistance to EGFR/ALK-TKIs in 23 centers across China from July 1, 2018 to Nov 23, 2022.

Research on Mine-Personnel Helmet Detection Based on Multi-Strategy-Improved YOLOv11.

In the complex environment of fully mechanized mining faces, the current object detection algorithms face significant challenges in achieving optimal accuracy and real-time detection of mine personnel and safety helmets. This difficulty arises from factors such as uneven lighting conditions and equipment obstructions, which often lead to missed detections. Consequently, these limitations pose a considerable challenge to effective mine safety management.