Aneuploidy of human granulosa cells in follicular fluids from in vitro fertilization patients.

Objectives: To study the proliferative behavior of granulosa cells found in follicular fluids from patients after hormone stimulation in the framework of in vitro fertilization (IVF) with gonadotropins.

Study Design: The deoxyribonucleic acid ploidy and the proliferation indices of granulosa cells in fresh and unfixed follicles (n = 119) from gonadotropin-stimulated patients (n = 32) were analyzed by flow cytometry.

Results: Aneuploid cells were found in a large number of follicles (65/119) as well as patients (25/32).

[Modified endocervical vaginal smear for diagnosis of endocervical microinvasive cervix carcinoma].

We report about a case of a highly intracervical located microcarcinoma of the cervix uteri, which could solely be diagnosed by a sufficient sampling technique using cyto-brush. The same case could not be diagnosed without the presence of endocervical cells in the endocervical smear either.

[CIN in pregnancy: incidence, diagnosis and therapy].

Over a period of 5 1/2 years, 71 cases of CIN in pregnancy were analysed. In this report, biological tumour behaviour, diagnostic procedures and therapy are discussed. In our study, there was a higher rate of remissions of light to moderate cervical intra-epithelial neoplasia (CIN I-II) in pregnancy than observed in non-pregnant women.

[Clinical aspects and morphology of extra-ovarian serous cancer of the pelvis].

An extraovarian peritoneal serous carcinoma is characterised macroscopically by ovaries without pathology, histologically, however, by a serous carcinomatous structure in the pelvis, in an advanced tumour stage of usually marked peritoneal carcinomatosis. Extraovarian pelvic serous carcinomas are rarely described in literature. In our study on five patients with such carcinomas, laparotomy findings revealed peritoneal carcinomatosis as in advanced ovarian carcinomas, but without ovarian involvement.

[Extent of psammoma carcinomas of the ovary--a clinical, DNA flow cytophotometric and morphometric image analysis study].

There is no agreement in literature on the biological behavior of psammoma carcinomas of the ovary. The majority of authors consider psammoma bodies to be the result of tumour regression, associating the occurrence of psammoma bodies with longer survival. On the other hand, several studies reveal a poor prognosis for psammoma carcinomas, similar to that of other epithelial malignant tumours.