Publications by authors named "H H Pfaeffle"
Objective: Pharmacokinetic variability drives tuberculosis (TB) treatment outcomes but measurement of serum drug concentrations for personalised dosing is inaccessible for children in TB-endemic settings. We compared rifampin urine excretion for prediction of a serum target associated with treatment outcome.
Design: Prospective diagnostic accuracy study.
Article Synopsis
- - At least one-third of tuberculosis (TB) cases go undiagnosed, particularly affecting children and adolescents, which complicates efforts to eliminate the disease globally.
- - A study conducted in rural Tanzania found that children with TB experienced respiratory symptoms for an average of 85 days before receiving treatment, with a significant number coming from households with TB exposure.
- - Interviews with families revealed that 94% of the 16 families reported TB severely impacted their children's education, highlighting the need for better screening to reduce symptom duration and school absenteeism.
Article Synopsis
- The study focuses on the experiences of children aged 4-17 with tuberculosis (TB) in low-income communities of northern Tanzania, exploring the challenges faced by them and their caregivers while seeking treatment.
- Interviews with 24 participants revealed significant socioemotional impacts on households, such as reduced work productivity and financial strain, with families spending a median of 34% of their monthly income on clinic visits.
- Caregivers highlighted potential solutions like transportation assistance and nutrition programs, emphasizing the need for healthcare systems to address the financial burdens and improve access to TB care for low-income families.
Utilization of a smart phone application paired with a time-spaced learning curriculum was investigated to determine its impact on antimicrobial stewardship practice among internal medicine trainees. Stewardship behaviors increased, barriers decreased, and trainees had increased confidence in managing common infectious disease syndromes after the intervention.
View Article and Find Full Text PDFBackground: /QUESTION: Nontuberculous mycobacteria (NTM) infections are increasingly detected but difficult to cure given complex drug-resistance patterns. Select U.S.
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