Publications by authors named "H H Marzook"
Article Synopsis
- - Dapagliflozin (DAPA) is an SGLT2 inhibitor with beneficial effects on heart cells, blood vessels, and insulin-producing beta cells, reducing hypertrophy and inflammation while improving cellular stress response.
- - The study found that DAPA activates the AKT pathway, decreases reactive oxygen species (ROS) production, and enhances glucose metabolism, contributing to its cardioprotective effects.
- - In aortic endothelial cells, DAPA showed anti-inflammatory effects and promoted better vascular function by regulating key signaling pathways and enhancing insulin function in beta cells, which could help manage diabetes.
The gut microbiota and its secreted metabolites play a significant role in cardiovascular and musculoskeletal health and diseases. The dysregulation of the intestinal microbiota poses a significant threat to cardiovascular and skeletal muscle well-being. Nonetheless, the precise molecular mechanisms underlying these changes remain unclear.
View Article and Find Full Text PDFDysregulated autophagy/mitophagy is one of the major causes of cardiac injury in ischemic conditions. Glycogen synthase kinase-3alpha (GSK-3α) has been shown to play a crucial role in the pathophysiology of cardiac diseases. However, the precise role of GSK-3α in cardiac mitophagy remains unknown.
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- * A study screened 70 natural compounds and identified Psoralidin and Rosmarinic acid as promising GSK-3 inhibitors, each showing stronger effects on their respective isoforms (Psoralidin for GSK-3α and Rosmarinic acid for GSK-3β).
- * The effectiveness of these compounds was confirmed through in silico docking and biochemical assays, but further research is needed to explore their potential benefits in treating cardiovascular, metabolic, and neurological conditions. *
Sodium-glucose cotransporter 2 (SGLT2) inhibitors have attracted significant attention for their broader therapeutic impact beyond simply controlling blood sugar levels, particularly in their ability to influence inflammatory pathways. This review delves into the anti-inflammatory properties of SGLT2 inhibitors, with a specific focus on canagliflozin, empagliflozin, and dapagliflozin. One of the key mechanisms through which SGLT2 inhibitors exert their anti-inflammatory effects is by activating AMP-activated protein kinase (AMPK), a crucial regulator of both cellular energy balance and inflammation.
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