Myocardial ischemia/reperfusion (IR) injury is a common adverse event in the clinical treatment of myocardial ischemic disease. Autosis is a form of cell death that occurs when autophagy is excessive in cells, and it has been associated with cardiac IR damage. This study aimed to investigate the regulatory mechanism of circRNA CDR1AS on autosis in cardiomyocytes under IR.
View Article and Find Full Text PDFNaunyn Schmiedebergs Arch Pharmacol
January 2025
Chrysoeriol (CHE) is a naturally occurring compound with established anti-inflammatory and anti-tumor effects. This study examines its potential role in regulating osteoclast differentiation and activity, both of which are crucial for bone remodeling. Computational docking revealed high binding affinity between CHE and RANKL, specifically at the Lys-181 residue of RANKL, suggesting potential inhibitory interactions on osteoclastogenesis.
View Article and Find Full Text PDFThis study presents a novel approach to identifying meters and their pointers in modern industrial scenarios using deep learning. We developed a neural network model that can detect gauges and one or more of their pointers on low-quality images. We use an encoder network, jump connections, and a modified Convolutional Block Attention Module (CBAM) to detect gauge panels and pointer keypoints in images.
View Article and Find Full Text PDFNaturally widespread ferrihydrite is unstable and often coexists with complex ions, such as the heavy metal ion Pb(II). Ferrihydrite could fix Pb(II) by precipitation and hydroxyl adsorption, but release Pb(II) with mineral aging. Gallic acid plays an important role in influencing the geochemical behavior of ferrihydrite-Pb, and anoxia is one of the factors influencing the transformation of mineral.
View Article and Find Full Text PDFBackground: With extended gefitinib treatment, the therapeutic effect in some non-small cell lung cancer (NSCLC) patients declined with the development of drug resistance. Aidi injection (ADI) is utilized in various cancers as a traditional Chinese medicine prescription. This study explores the molecular mechanism by which ADI, when combined with gefitinib, attenuates gefitinib resistance in PC9GR NSCLC cells.
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