Publications by authors named "H H L M Goossens"
Background: Illness severity, comorbidity, fever, age and symptom duration influence antibiotic prescribing for respiratory tract infections (RTI). Non-medical determinants, such as patient expectations, also impact prescribing.
Aim: To quantify the effect of general practitioners' (GPs') perception of a patient request for antibiotics on antibiotic prescribing for RTI and investigate effect modification by medical determinants and country.
Background: The impact of community carriage on the influx of extended-spectrum beta-lactamase-producing Enterobacterales (ESBL-E) into hospitals remains understudied. In this prospective 2-year single-centre study, we investigate the community ESBL-E influx and trace the colonisation, nosocomial acquisition, transmission, and infection dynamics of ESBL-producing Escherichia coli (ESBL-Ec) in non-ICU wards at a tertiary care hospital.
Methods: This study reports primary and post hoc outcomes of the clinical trial NCT01208519 in which hospitalised patients were screened for rectal carriage of ESBL-E.
Article Synopsis
- An opportunistic pathogen caused an 18-month outbreak in a neonatal intensive care unit (NICU) in Antwerp, Belgium, affecting 61 neonates, with ten confirmed infections resulting in serious conditions, including one fatal case.
- The risk of acquiring the infection was significantly higher in neonates nursing in incubators, highlighted by statistical analysis (OR: 2.99; p < 0.05).
- Whole genome sequencing revealed multiple clusters and the importance of ongoing surveillance and specific infection control measures in NICUs to prevent similar outbreaks in the future.
Background: The Global Point Prevalence Survey (PPS) of antimicrobial consumption and resistance has been widely undertaken to combat the global threat of antimicrobial resistance (AMR). This study was conducted in alignment with the Global-PPS in three tertiary care hospitals in Kerman, Iran, to evaluate antimicrobial consumption patterns.
Methods: The study was conducted from January 2020 to January 2021 in Afzalipour, Shafa, and Shahid Bahonar Hospitals.
Objectives: Pseudomonas aeruginosa (PA) is a common causative pathogen of pneumonia acquired in the intensive care unit (ICU). The aim of this study was to determine the incidence of PA ICU pneumonia (PAIP) and to quantify its independent association with PA colonization at different body sites.
Methods: Adult patients on mechanical ventilation at ICU admission were prospectively enrolled across 30 European ICUs.